Diamond-like carbon coating and surface grafting of osteoprotegerin and alendronate on polyetheretherketone to ameliorate the mechanical performance and osseointegration simultaneously

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3D-printed porous PEEK scaffold combined with CSMA/POSS bioactive surface: A strategy for enhancing osseointegration of PEEK implants

Zhewen Liu et al.

Summary: By integrating the modified CSMA/POSS bioactive microporous surface with PEEK scaffolds, enhanced protein adsorption and bone formation can be achieved, showing promising potential for improving osseointegration.

COMPOSITES PART B-ENGINEERING (2022)

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Article Engineering, Biomedical

Rational integration of defense and repair synergy on PEEK osteoimplants via biomimetic peptide clicking strategy

Meng Li et al.

Summary: This study proposes a biomimetic surface strategy for the rational integration and optimization of anti-infectivity and osteo-inductivity onto PEEK surfaces using a mussel foot proteins (Mfps)-mimic peptide. By employing bioorthogonal clicking, antimicrobial peptide (AMP) and osteogenic growth peptide (OGP) were precisely located on the azido-modified PEEK surfaces, resulting in a dual-effect of host defense and tissue repair.

BIOACTIVE MATERIALS (2022)

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Article Engineering, Multidisciplinary

Additively-manufactured PEEK/HA porous scaffolds with excellent osteogenesis for bone tissue repairing

Jibao Zheng et al.

Summary: PEEK/HA scaffolds improved osseointegration with host bone and enhanced the activity of BMSCs. Micro-CT and histological staining results showed higher bone ingrowth volume and better osteointegration effect of PEEK/HA scaffolds in comparison to pure PEEK scaffolds.

COMPOSITES PART B-ENGINEERING (2022)

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Article Engineering, Biomedical

A micro/nano-biomimetic coating on titanium orchestrates osteo/angio-genesis and osteoimmunomodulation for advanced osseointegration

Long Bai et al.

Summary: The study developed a biomimetic implant coating that regulated the participatory processes during osseointegration, showing promising results in in vitro experiments.

BIOMATERIALS (2021)

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Article Engineering, Biomedical

High-strength, porous additively manufactured implants with optimized mechanical osseointegration

Cambre N. Kelly et al.

Summary: The optimization of porous titanium alloy scaffolds for orthopedic implants involves balancing mechanical properties and osseointegrative performance. Research findings suggest a complex relationship between scaffold porosity and performance, with a linear relationship observed between porosity and benchtop mechanical properties, and a non-linear relationship observed between porosity and ex vivo cortical bone-implant interfacial shear strength.

BIOMATERIALS (2021)

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Review Engineering, Biomedical

Modification of polyetheretherketone implants: From enhancing bone integration to enabling multi-modal therapeutics

Miaomiao He et al.

Summary: PEEK, a popular thermoplastic material, has been widely used in the biomedical field due to its favorable mechanical properties. The demand for next-generation implants with enhanced treatment efficacy has led to the development of PEEK modification for multi-modal therapeutics, such as fast bone integration and therapeutic functions. The progress in PEEK processing and modification techniques has significantly contributed to its wide applications in the biomedical field.

ACTA BIOMATERIALIA (2021)

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Article Engineering, Multidisciplinary

Mechanical and thermal properties of PEEK composites by incorporating inorganic particles modified phosphates

Yongan Niu et al.

Summary: This study successfully improved the heat resistance of PEEK composites by adding different types of phosphate reinforcements, with Al2O3 modified phosphate standing out in enhancing the 30% weight loss temperature and compressive strength.

COMPOSITES PART B-ENGINEERING (2021)

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Article Chemistry, Multidisciplinary

Nutrient Element Decorated Polyetheretherketone Implants Steer Mitochondrial Dynamics for Boosted Diabetic Osseointegration

Hao Wang et al.

Summary: This study introduced a novel mitochondria-targeted orthopedic implant with Zn2+ and Sr2+ modulation capability for enhancing bone formation and osseointegration in diabetic patients. The implant demonstrated the ability to recuperate mitochondrial dynamic disequilibrium and dysfunction in hyperglycemic conditions, ultimately enhancing osteogenicity of osteoblasts. In vivo evaluations further confirmed that nutrient element coatings substantially augment bone remodeling and osseointegration.

ADVANCED SCIENCE (2021)

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Article Engineering, Biomedical

Tuning the surface immunomodulatory functions of polyetheretherketone for enhanced osseointegration

Ang Gao et al.

BIOMATERIALS (2020)

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Article Engineering, Environmental

Dimensional-dependent antibacterial behavior on bioactive micro/nano polyetheretherketone (PEEK) arrays

Shi Mo et al.

CHEMICAL ENGINEERING JOURNAL (2020)

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Article Engineering, Multidisciplinary

Multifunctional performance of carbon nanotubes and graphene nanoplatelets reinforced PEEK composites enabled via FFF additive manufacturing

M. F. Arif et al.

COMPOSITES PART B-ENGINEERING (2020)

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Article Endocrinology & Metabolism

History of alendronate

Steven R. Cummings et al.

BONE (2020)

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Article Nanoscience & Nanotechnology

MXene-Based Hydrogels Endow Polyetheretherketone with Effective Osteogenicity and Combined Treatment of Osteosarcoma and Bacterial Infection

Jie Yin et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Engineering, Biomedical

Biomimetic osteogenic peptide with mussel adhesion and osteoimmunomodulatory functions to ameliorate interfacial osseointegration under chronic inflammation

Jiaxiang Bai et al.

BIOMATERIALS (2020)

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Article Engineering, Multidisciplinary

Preparation of short CF/GF reinforced PEEK composite filaments and their comprehensive properties evaluation for FDM-3D printing

Peng Wang et al.

COMPOSITES PART B-ENGINEERING (2020)

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Article Cell Biology

Local Production of Osteoprotegerin by Osteoblasts Suppresses Bone Resorption

Keisha M. Cawley et al.

CELL REPORTS (2020)

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A new alendronate doped HAP nanomaterial for Pb2+, Cu2+ and Cd2+ effect absorption

Jianzhe Ma et al.

JOURNAL OF HAZARDOUS MATERIALS (2020)

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Review Biochemistry & Molecular Biology

The Role of Osteoprotegerin and Its Ligands in Vascular Function

Luc Rochette et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Strengthening the potential of biomineralized microspheres in enhancing osteogenesis via incorporating alendronate

Pengfei Wei et al.

CHEMICAL ENGINEERING JOURNAL (2019)

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Review Materials Science, Biomaterials

Total knee arthroplasty application of polyetheretherketone and carbon-fiber-reinforced polyetheretherketone: A review

Yong-Gon Koh et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

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Article Multidisciplinary Sciences

Osteoprotegerin reduces osteoclast resorption activity without affecting osteogenesis on nanoparticulate mineralized collagen scaffolds

Xiaoyan Ren et al.

SCIENCE ADVANCES (2019)

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Review Engineering, Biomedical

Bisphosphonate-Functionalized Scaffolds for Enhanced Bone Regeneration

Yutao Cui et al.

ADVANCED HEALTHCARE MATERIALS (2019)

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Review Materials Science, Biomaterials

Biopolymers as bone substitutes: a review

Anastasiia Kashirina et al.

BIOMATERIALS SCIENCE (2019)

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Review Immunology

Osteoimmunology: evolving concepts in bone-immune interactions in health and disease

Masayuki Tsukasaki et al.

NATURE REVIEWS IMMUNOLOGY (2019)

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Biofunctional Mg coating on PEEK for improving bioactivity

Xiaoming Yu et al.

BIOACTIVE MATERIALS (2018)

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Review Clinical Neurology

Titanium vs. polyetheretherketone (PEEK) interbody fusion: Meta-analysis and review of the literature

Scott Seaman et al.

JOURNAL OF CLINICAL NEUROSCIENCE (2017)

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Article Materials Science, Biomaterials

Improved biotribological properties of PEEK by photo-induced graft polymerization of acrylic acid

Xiaoduo Zhao et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2017)

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Article Materials Science, Coatings & Films

Combination of laser surface texturing and DLC coating on PEEK for enhanced tribological properties

Johnny Dufils et al.

SURFACE & COATINGS TECHNOLOGY (2017)

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Article Materials Science, Multidisciplinary

Significantly enhanced wear resistance of PEEK by simply filling with modified graphitic carbon nitride

Ligang Zhang et al.

MATERIALS & DESIGN (2017)

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Linker-free covalent immobilization of heparin, SDF-1α, and CD47 on PTFE surface for antithrombogenicity, endothelialization and anti-inflammation

Ang Gao et al.

BIOMATERIALS (2017)

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Review Chemistry, Multidisciplinary

Free-Radical-Induced Grafting from Plasma Polymer Surfaces

Farid Khelifa et al.

CHEMICAL REVIEWS (2016)

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Article Nanoscience & Nanotechnology

Effects of Carbon and Nitrogen Plasma Immersion Ion Implantation on In vitro and In vivo Biocompatibility of Titanium Alloy

Ying Zhao et al.

ACS APPLIED MATERIALS & INTERFACES (2013)

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Review Engineering, Biomedical

Osteolysis around total knee arthroplasty: A review of pathogenetic mechanisms

J. Gallo et al.

ACTA BIOMATERIALIA (2013)

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Article Engineering, Biomedical

Cytocompatibility, osseointegration, and bioactivity of three-dimensional porous and nanostructured network on polyetheretherketone

Ying Zhao et al.

BIOMATERIALS (2013)

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Article Engineering, Biomedical

Mechanical and biological characteristics of diamond-like carbon coated poly aryl-ether-ether-ketone

Huaiyu Wang et al.

BIOMATERIALS (2010)

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Article Engineering, Biomedical

The electron beam deposition of titanium on polyetheretherketone (PEEK) and the resulting enhanced biological properties

Cheol-Min Han et al.

BIOMATERIALS (2010)

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Article Engineering, Biomedical

The in vitro response of human osteoblasts to polyetheretherketone (PEEK) substrates compared to commercially pure titanium

Karen B. Sagomonyants et al.

BIOMATERIALS (2008)

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Review Engineering, Biomedical

PEEK biomaterials in trauma, orthopedic, and spinal implants

Steven M. Kurtz et al.

BIOMATERIALS (2007)

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Article Engineering, Biomedical

Plasma surface modification of poly vinyl chloride for improvement of antibacterial properties

W Zhang et al.

BIOMATERIALS (2006)

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Article Engineering, Biomedical

Improvement of surface bioactivity on titanium by water and hydrogen plasma immersion ion implantation

YT Xie et al.

BIOMATERIALS (2005)

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Article Multidisciplinary Sciences

Effects of mechanical forces on maintenance and adaptation of form in trabecular bone

R Huiskes et al.

NATURE (2000)

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Review Multidisciplinary Sciences

Therapeutic approaches to bone diseases

GA Rodan et al.

SCIENCE (2000)

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Diamond-like carbon coating and surface grafting of osteoprotegerin and alendronate on polyetheretherketone to ameliorate the mechanical performance and osseointegration simultaneously

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