期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 87, 期 -, 页码 3-14出版社
ELSEVIER
DOI: 10.1016/j.addr.2015.05.001
关键词
miRNA; MicroRNA; Dicer; Drosha; Argonaute; RNAi
资金
- NIH [R01GM070674, RC1HL100108]
- Department of Cell Biology and Physiology
The discovery of the first microRNA (miRNA) over 20 years ago has ushered in a new era in molecular biology. There are now over 2000 miRNAs that have been discovered in humans and it is believed that they collectively regulate one third of the genes in the genome. miRNAs have been linked to many human diseases and are being pursued as clinical diagnostics and as therapeutic targets. This review presents an overview of the miRNA pathway, including biogenesis routes, biological roles, and clinical approaches. (C) 2015 Elsevier B.V. All rights reserved.
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