期刊
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
卷 255, 期 -, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cbpc.2022.109289
关键词
Cadmium; Drosophila; Toxicity; Metal homeostasis; Antioxidant enzyme
资金
- UGC, India
This study utilized fruit flies to assess the effects of cadmium on animal behavior, revealing reduced locomotion and reproductive fitness after cadmium exposure. Transgenerational effects on locomotion were behavior-specific, and decreased antioxidant enzyme activity and altered essential element balance may be responsible for these effects.
Cadmium (Cd) exerts detrimental effects on multiple biological processes of the living organisms along with epigenetic transgenerational effect. Drosophila melanogaster offers unique opportunity to evaluate Cd toxicity when studying important life traits in short duration of time by designing distinct behavioural assays. Present study utilized this model organism to assess Cd induced lethality, retarded growth, decreased life span and altered behaviour of the animals either at larval or adult stage. Our investigations revealed reduced locomotion and reproductive fitness of the animals upon Cd exposure. Transgenerational effect on locomotion was found to be behaviour specific as larval crawling was affected, but adult fly negative geotaxis was comparable to the control. Mechanistically, decreased antioxidant enzymes activity, superoxide dismutase (SOD) and catalase (CAT) together with altered homeostasis of essential elements (Fe, Zn and Mg) may be responsible for the observed effects. Altogether our work showed extensive range of Cd altered Drosophila behaviour which warrants need to control environmental Cd toxicity.
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