期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 214, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2022.112480
关键词
Nanofibrous medical dressing; Diabetic foot ulcer; Polycaprolactone; Collagen; One-time dressing change
资金
- Natural Science Foun-dation of Guangdong Province, China [2019A1515011769]
- Guangdong Science and Technology Major Special Fund, China [2019-252]
- Foundation of Higher Education of Guangdong, China [2020ZDZX2038]
- Science Foundation for Young Research Group of Wuyi University [2019td08]
- Guangdong/Hong Kong Joint Foundation of Wuyi University [2019WGALH11]
- Guangdong Basic and Applied Basic Research Foundation [2021A1515110510]
- Project of Educational Commission of Guangdong Province, China [2021KQNCX102]
Nanofibrous dressings have significant technological implications for treating diabetic foot ulcers (DFUs) due to their high specific surface areas, good histocompatibility, enhanced wound healing, and reduced inflammation. In this study, a 3D polycaprolactone/collagen nanofibrous dressing loaded with matrix metalloproteinases inhibitor and antibacterial agent showed high water absorption capacity, antibacterial activity, and biocompatibility, providing a potential candidate for promoting DFU wound healing.
Nanofibrous dressings exhibit high specific surface areas, good histocompatibility, enhanced wound healing, and reduced inflammation, which have broad technological implications for treating diabetic foot ulcers (DFUs). However, current nanofibrous dressings still suffer from high resistance to cell infiltration and multiple dressing changes. In this study, polycaprolactone (PCL) and collagen were adopted as electrospinning materials to prepare a 3D PCL/Collagen (PC) nanofibrous dressing (3D-PC) using aqueous phase fibre reassembly technology. The matrix metalloproteinases (MMPs) inhibitor doxycycline hyclate (DCH)-loaded halloysite nanotubes (HNTs) (DCH@HNTs) and antibacterial agent cephalexin (CEX) were loaded onto the dressing to prepare a multifunctional 3D drug-loaded PCL/Collagen nanofibrous dressing to promote DFU wound healing. The obtained 3D nanofibrous dressing exhibited high water absorption capacity and swelling capacity. It showed good antibacterial activity against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) in vitro antibacterial test. In addition, the 3D nanofibrous dressing demonstrated good biocompatibility. It could significantly reduce the frequency of dressing changes and improve the healing of DFU wounds compared with the conventional multiple dressing changes method, suggesting a potential candidate for healing diabetic wounds.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据