4.7 Article

Manganese complexes and manganese-based metal-organic frameworks as contrast agents in MRI and chemotherapeutics agents: Applications and prospects

期刊

出版社

ELSEVIER
DOI: 10.1016/j.colsurfb.2022.112432

关键词

Manganese complexes; Manganese-MOF; MRI; Contrast agents; Antibacterial; Anti-tumor

资金

  1. Guangdong Province Univer-sities and Colleges Pearl River Scholar Fund [4SG21006G]
  2. Guang-dong Basic and Applied Basic Research Foundation [2019A1515110260]
  3. Guangdong Basic and Applied Basic Research Foundation [2021A1515011616, 20211227]
  4. Featured Innovation Project of Guangdong Province [2019KTSCX052, 2019KTSCX053]
  5. Special Funds for Scientific Technological Innovation of Undergraduates in Guangdong Province [pdjh2021a0218]
  6. Public Research and Capacity Building Projects of Department of Guangdong Province [2017A010103022]
  7. Key scientific research project of Colleges and Universities of Edu-cation Department of Guangdong Province [20202ZDZX2046, 2021ZDZX2052]
  8. Natural Science Foundation of Guangdong Medi-cal University [GDMUM2020022]

向作者/读者索取更多资源

Manganese-based Metal-organic Frameworks (Mn-MOFs) have significant potential in biomedical applications, especially in imaging, anti-tumor therapy, and antimicrobial applications. The low toxicity, oxidative ability, and biocompatibility of Mn-MOFs make them highly desirable in medical field. Manganese complexes also show promising prospects in drug targeting.
Manganese-based Metal-organic Frameworks (Mn-MOFs) represents a unique sub-class of MOFs with low toxicity, oxidative ability, and biocompatibility, which plays vital role in the application of this class of MOFs in medical field. Mn-MOFs show great potential in biomedical applications, and has been extensively studied as compared to other MOFs in transition metal series. They are important in medical applications because Mn(II) possess large electron spin number and longer electron relaxation time. They display fast water exchange rate and could be employed as a potential MRI contrast agent because of their strong targeting ability. Manganese complexes with different ligands also display prospective applications in area such as carrier for drug targeting in anti-tumor and antimicrobial therapy. In the review presented herewith, the application of Mn-based complexes and Mn-MOFs have been emphasized in the area such as imaging viz. MRI, multimodal imaging, antitumor activities such as chemodynamic therapy, photodynamic therapy, sonodynamic therapy and antimicrobial applications. Also, how rational designing and syntheses of targeted Mn-based complexes and Mn-MOFs can engender desired applications.

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