期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 211, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2021.112316
关键词
Natural derived components; Oxidized bacterial cellulose; Nano hydroxyapatite; Bone regeneration
资金
- Science Fund of Shandong Laboratory of Advanced Materials and Green Manufacturing (Yantai) [AMGM2021F02]
- State Key Laboratory of Advanced Technology for Materials Synthesis and Processing (Wuhan University of Technology)
- Physical-Chemical Materials Analytical & Testing Center of Shandong University at Weihai
Bone tissue engineering plays a significant role in bone defect repair and regeneration. This article introduces a low-cost manufacturing method for a new bone repair composite scaffold that shows improved mechanical properties and stability compared to other scaffolds, promoting cell proliferation and bone tissue formation.
Bone tissue engineering has been widely used in promoting the repair and regeneration of bone defects. Tissue-engineered bone scaffolds can simulate the extracellular matrix environment and induce the proliferation and differentiation of osteoblasts. The first issues to be considered when constructing bone repair scaffolds include biocompatibility, stress resistance, degradability and stability. Here, a low-cost manufacturing introduces a new bone repair composite scaffold (CS/OBC/nHAP). The scaffolds were composed of only natural derived components, including nano hydroxyapatite (nHAP) formed by in-situ crystallization of Ca2+/PO42- solution and evenly dispersed in oxidized bacterial cellulose (OBC) and chitosan (CS) scaffolds. The experimental results showed that compared with CS/nHAP scaffold, CS/OBC/nHAP scaffold has significantly improve mechanical properties and water retention performance, and has a more stable degradation rate. Cell experiments showed that the CS/OBC/nHAP scaffold has good biocompatibility and significantly promote the proliferation of MC3T3-E1 cells. The rat skull defect model further proves that the CS/OBC/nHAP scaffold could induce the formation of bone tissue. Meanwhile, H&E staining experiment show that the CS/OBC/nHAP scaffold has good stability in vivo and could better promote the formation of bone tissue.
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