4.7 Article

In vitro and in vivo highly effective antibacterial activity of carbon dots-modified TiO2 nanorod arrays on titanium

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ELSEVIER
DOI: 10.1016/j.colsurfb.2022.112318

关键词

Carbon dots; Photo-sensitive coating; Titanium; Antibacterial property; Biocompatibility

资金

  1. National Natural Science Foundation of China [52171240, 31700834]
  2. Postdoctoral Science Foundation of China [2021M691992]
  3. Major Projects in Research and Development of Shanxi [201803D421090]
  4. Natural Science Foundation of Special Equipment Safety Supervision Inspection Institute of Jiangsu Province [2020037]

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Light-triggered antibacterial therapy using carbon dots and titanium dioxide nanorods shows improved antibacterial ability of titanium implants under visible light and near-infrared light, and enhances the adhesion and diffusion of bone marrow mesenchymal stem cells.
Light-triggered antibacterial therapy has been proven to be a secure and effective way to treat bacterial infection. Nevertheless, the long-term security of the common photosensitizer remains to be seen in the body. In this work, carbon dots (CDs) with good biocompatibility are incorporated into TiO2 nanorods to improve the photocatalytic and photothermal ability of titanium implants under the irradiation of visible light (VL) and near-infrared (NIR) light. The C-TiO2 NR exhibit excellent in vitro and in vivo antimicrobial effect under 660 nm VL and 808 nm NIR light co-irradiation owing to the combined effect of hyperthermia, reactive oxygen species (ROS) and nanorod structure. Besides, C-TiO2 NR can improve the adhesion and diffusion of bone marrow mesenchymal stem cells (BMSCs).

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