Bimetallic gold-platinum nanoparticles as a drug delivery system coated with a new drug to target glioblastoma

A drug delivery nanosystem of noble bimetallic nanoparticles (NPs) which consists of Au NPs capped with Pt NPs (Au@Pt NPs) is constructed and functionalised with a quinazoline based small molecule (Au@Pt@Q NPs), acting as a theranostic agent against glioblastoma. Two different hydrothermal synthetic procedures for bimetallic Au@Pt NPs are presented and the resulting nanostructures are fully characterised by means of spectroscopic and microscopic methods. The imaging and targeting capacity of the new drug delivery system is assessed through fluorescent optical microscopy and cytotoxicity evaluations. The constructed Au@Pt NPs consist a mono dispersed colloidal solution of 25 nm with photoluminescent, fluorescent and X-Ray absorption properties that confirm their diagnostic potential. Haemolysis testing demonstrated that Au@Pt NPs are biocompatible and fluorescent microscopy confirmed their entering the cells. Cytological evaluation of the NPs through MTT assay showed that they do not inhibit the proliferation of control cell line HEK293, whereas they are toxic in U87MG, U251 and D54 glioblastoma cell lines; rendering them selective targeting agents for treating glioblastoma.

Automated summary

In this study, a drug delivery nanosystem consisting of noble bimetallic nanoparticles and functionalised with a small molecule was constructed for theranostic treatment of glioblastoma. The nanoparticles exhibited excellent imaging and targeting capacity, confirming their potential as a diagnostic agent. They also demonstrated selective cytotoxicity in glioblastoma cell lines, making them a promising targeted therapy for glioblastoma.