Wound infections preventing using antibacterial chitosan/Laurus nobilis essential oil emulsion on PET braided surgical sutures

In this study, chitosan/Laurus nobilis essential oil (CH/LEO) emulsion was formed as an antibacterial agent and fixed on PET braided sutures using a pad-dry process. Infrared spectra and droplet size distribution were used to characterize the physical and chemical structure of the emulsion. In-vitro antibacterial activity was tested against gram-positive and gram-negative microorganisms. The obtained emulsions showed a poly-modal distribution with a mean particle size of 1.172 mu m and good antibacterial activities. In order to maximize the amount of CH/ LEO emulsion in the suture surface, the effect of manufacturing conditions has been studied. Infrared spectroscopy confirmed the presence of the emulsion on the suture surface. The mechanical performance of developed sutures was evaluated according to USP pharmacopeia recommendations and antibacterial effects of developed sutures against gram-positive and gram-negative bacteria were checked. Results show an effective antibacterial effect with good mechanical performances.

Automated summary

Chitosan/Laurus nobilis essential oil emulsion was prepared and fixed on PET braided sutures, showing good antibacterial activity and mechanical performance.