期刊
CLINICAL THERAPEUTICS
卷 44, 期 4, 页码 624-629出版社
ELSEVIER
DOI: 10.1016/j.clinthera.2022.02.007
关键词
burns; meropenem; pharmacodynamics; pharmacokinetics; sepsis
The purpose of this prospective cohort study was to evaluate the therapeutic target achievement of 3-hour extended infusion of meropenem in patients with septic burns in the early and late periods of septic shock. The study found that the therapeutic target was achieved when treating infections caused by gram-negative bacteria, such as Pseudomonas aeruginosa.
Purpose: The aim of this prospective cohort study was to evaluate the therapeutic target attainment of 3-hour extended infusion of meropenem in patients with septic burns in the early and late periods of septic shock. Methods: Meropenem serum levels were determined by liquid chromatography from blood samples collected within 48 hours (early period) of therapy and 10 to 14 days afterward (late period). Pharmacokinetic properties were investigated by noncompartmental analysis, and the therapeutic target was defined as 100% of the time above the MIC (100%fT> MIC). Findings: Fifteen patients with 90 measured meropenem concentrations were included. Throughout the entire course of antimicrobial therapy, the therapeutic target was attained against gram-negative pathogens with an MIC <= 2 mg/L. Pathogens with intermediate susceptibility to meropenem were only covered in the early phase of therapy. (C) 2022 Elsevier Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据