4.7 Review

Autophagy in asthma and chronic obstructive pulmonary disease

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cell Biology

Cannabidiol activates PINK1-Parkin-dependent mitophagy and mitochondrial-derived vesicles

Adrian Ramirez et al.

Summary: The PINK1/Parkin pathway is essential for maintaining a healthy pool of mitochondria, and CBD has been found to activate this pathway in a unique manner. CBD can stimulate the production of mitochondrial-derived vesicles (MDV) through the PINK1/Parkin pathway, which may help repair damaged mitochondria and contribute to overall mitochondrial health.

EUROPEAN JOURNAL OF CELL BIOLOGY (2022)

Review Allergy

The effect of statins for asthma. A systematic review and meta-analysis

Keeya Sunata et al.

Summary: Statins have the potential to significantly improve asthma control and reduce asthma exacerbation without any improvement in pulmonary function, as demonstrated by a meta-analysis of clinical studies.

JOURNAL OF ASTHMA (2022)

Review Allergy

Dupilumab: A Review of Present Indications and Off-Label Uses

F. J. Munoz-Bellido et al.

Summary: Recent advances in understanding T2 inflammation have identified more diseases involved in this process. Dupilumab, a monoclonal antibody that blocks IL-4 and IL-13 signaling, shows potential for various skin and respiratory diseases as well as eosinophilic gastrointestinal disorders and food allergy.

JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY (2022)

Article Pharmacology & Pharmacy

Metformin Ameliorates Inflammation and Airway Remodeling of Experimental Allergic Asthma in Mice by Restoring AMPKα Activity

Wenxian Ma et al.

Summary: This study demonstrates that metformin can alleviate airway inflammation and remodeling in an OVA-induced chronic asthmatic model. The protective effects of metformin may be associated with the restoration of AMPKα activity and decreased asthma-related angiogenesis.

FRONTIERS IN PHARMACOLOGY (2022)

Article Biochemistry & Molecular Biology

A Guide To horizontal ellipsis The regulation of selective autophagy receptors

Andrea Gubas et al.

Summary: Autophagy is a highly conserved cellular process for degrading abnormal cellular components and foreign pathogens, which can be selective or nonselective. Autophagy receptors play a crucial role in linking and degrading cell components during autophagy, undergoing structural modifications to fulfill their function.

FEBS JOURNAL (2022)

Article Cell Biology

Mitophagy: Molecular Mechanisms, New Concepts on Parkin Activation and the Emerging Role of AMPK/ULK1 Axis

Roberto Iorio et al.

Summary: Mitochondria are critical organelles for cellular energy balance and cell death. Mitophagy, the selective removal of dysfunctional mitochondria by autophagy, plays important roles in maintaining mitochondrial health. Both impaired and excessive mitophagy are involved in various ageing-associated diseases. Recent advances have explored the molecular mechanisms and signaling pathways that regulate mitophagy, including the early role and spatial specificity of the AMPK/ULK1 axis.
Article Allergy

Role of autophagy in regulating interleukin-10 and the responses to corticosteroids and statins in asthma

Kittipong Maneechotesuwan et al.

Summary: This study investigated the role of autophagy in promoting inflammation in asthma through reducing IL-10 secretion in macrophages. It found that corticosteroids and statins inhibit autophagy in macrophages, leading to increased IL-10 production and control of asthmatic inflammation.

CLINICAL AND EXPERIMENTAL ALLERGY (2021)

Article Multidisciplinary Sciences

Cigarette smoke-induced impairment of autophagy in macrophages increases galectin-8 and inflammation

Yuta Kono et al.

Summary: Cigarette smoke impairs cellular autophagy, leading to increased levels of galectin-8, which may be involved in the pathogenesis of chronic obstructive pulmonary disease (COPD).

SCIENTIFIC REPORTS (2021)

Review Cell Biology

Cardiac Glycosides as Autophagy Modulators

Jan Skubnik et al.

Summary: Drug repositioning is a leading strategy in modern therapeutic research, focusing on repurposing commonly used drugs for new clinical applications. Cardiac glycosides, traditionally used for heart conditions, have been found to possess anticancer properties and are being investigated for potential use in cancer therapy with autophagy playing a key role in their mechanism of action.
Article Critical Care Medicine

Metformin: Experimental and Clinical Evidence for a Potential Role in Emphysema Treatment

Francesca Polverino et al.

Summary: This study demonstrated that metformin can protect against smoking-induced lung pathology in animal models, and in humans, metformin use is associated with a slower progression of emphysema. These findings suggest the potential of metformin in limiting emphysema progression and its systemic consequences.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2021)

Review Biochemistry & Molecular Biology

Autophagy: A Friend or Foe in Allergic Asthma?

Efthymia Theofani et al.

Summary: Autophagy is a crucial self-degradative process in cells that plays a key role in cellular renovation, physiology, and homeostasis. It can be triggered by factors such as starvation, pathogens, and stress, and is important in immune response regulation. Dysregulation of autophagy processes, either impaired or overactive, can contribute to the pathogenesis of various diseases, including infections and cancer.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Immunology

Impaired TRIM16-Mediated Lysophagy in Chronic Obstructive Pulmonary Disease Pathogenesis

Jun Araya et al.

Summary: Insufficient autophagic degradation has been implicated in accelerated cellular senescence during COPD pathogenesis. TRIM16-mediated lysophagy plays a crucial role in regulating cigarette smoke-induced lysosomal damage and cellular senescence in airway epithelial cells. Damaged lysosomes with LMP accumulation in COPD lungs may contribute to impaired TRIM16-mediated lysophagy and enhanced cellular senescence.

JOURNAL OF IMMUNOLOGY (2021)

Review Pharmacology & Pharmacy

Autophagy Modulators From Chinese Herbal Medicines: Mechanisms and Therapeutic Potentials for Asthma

Yun Zhang et al.

Summary: Asthma is a global health issue affecting over 300 million people worldwide, and treatment options include using different agents targeting different pathways. Autophagy modulation may offer new therapeutic approaches for asthma.

FRONTIERS IN PHARMACOLOGY (2021)

Review Cell Biology

Autophagy in healthy aging and disease

Yahyah Aman et al.

Summary: This Review discusses the recent research on the mechanisms and roles of autophagy in health, aging, and disease, and how drugs modulating autophagy process could be used to suppress age-associated diseases. It examines emerging features of autophagy and proposes the potential links to aging and disease progression. The review also highlights the importance of understanding the interplay between autophagy and age-related pathologies for the development of clinical applications promoting long-term health.

NATURE AGING (2021)

Article Respiratory System

Defective monocyte-derived macrophage phagocytosis is associated with exacerbation frequency in COPD

R. Singh et al.

Summary: The study found that impaired COPD macrophage phagocytosis of Haemophilus influenzae, but not Streptococcus pneumoniae, is associated with exacerbation frequency, resulting in the formation of pro-inflammatory macrophages in these frequent exacerbators. Targeting drugs to improve macrophage phagocytosis in these patients may be beneficial in disease management.

RESPIRATORY RESEARCH (2021)

Review Cell Biology

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky et al.

Summary: The guidelines presented in this article aim to assist researchers in selecting and interpreting methods to examine autophagy, as well as to help reviewers provide constructive critiques of reports focused on these processes. It emphasizes that no single assay is perfect for every situation, and multiple techniques may be needed to properly monitor autophagy in different experimental settings. The article also highlights the importance of targeting multiple autophagy-related genes in genetic approaches to block autophagy effectively.

AUTOPHAGY (2021)

Article Allergy

Autophagy is critical for group 2 innate lymphoid cell metabolic homeostasis and effector function

Lauriane Galle-Treger et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

Review Cell Biology

Modulatory effects of statins on the autophagy: A therapeutic perspective

Milad Ashrafizadeh et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2020)

Review Cell Biology

Lysosomes as dynamic regulators of cell and organismal homeostasis

Andrea Ballabio et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

Article Geriatrics & Gerontology

A randomized crossover trial of elamipretide in adults with primary mitochondrial myopathy

Amel Karaa et al.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2020)

Review Cell Biology

Mitophagy pathways in health and disease

Samuel A. Killackey et al.

JOURNAL OF CELL BIOLOGY (2020)

Review Immunology

Interplay Between NLRP3 Inflammasome and Autophagy

Monika Biasizzo et al.

FRONTIERS IN IMMUNOLOGY (2020)

Article Respiratory System

Mitochondrial dysfunction in lung ageing and disease

Suzanne M. Cloonan et al.

EUROPEAN RESPIRATORY REVIEW (2020)

Review Biochemistry & Molecular Biology

Autophagy and Autophagy-Related Diseases: A Review

Tadashi Ichimiya et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Multidisciplinary Sciences

Enhanced mitophagy in bronchial fibroblasts from severe asthmatic patients

Rakhee K. Ramakrishnan et al.

PLOS ONE (2020)

Article Respiratory System

Defective bacterial phagocytosis is associated with dysfunctional mitochondria in COPD macrophages

Kylie B. R. Belchamber et al.

EUROPEAN RESPIRATORY JOURNAL (2019)

Review Cell Biology

Roles of mTOR Signaling in Tissue Regeneration

Xiangyong Wei et al.

Article Biochemistry & Molecular Biology

Autophagy Activation in Asthma Airways Remodeling

Kielan D. McAlinden et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2019)

Review Biochemistry & Molecular Biology

Biological Functions of Autophagy Genes: A Disease Perspective

Beth Levine et al.

Review Critical Care Medicine

Cellular Senescence as a Mechanism and Target in Chronic Lung Diseases

Peter J. Barnes et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2019)

Article Biochemistry & Molecular Biology

Bicaudal D1 impairs autophagosome maturation in chronic obstructive pulmonary disease

Nicolas Mercado et al.

FASEB BIOADVANCES (2019)

Article Respiratory System

Association of Metformin Initiation and Risk of Asthma Exacerbation A Claims-based Cohort Study

Tianshi David Wu et al.

ANNALS OF THE AMERICAN THORACIC SOCIETY (2019)

Article Cell Biology

Cigarette smoke-induced autophagy impairment accelerates lung aging, COPD-emphysema exacerbations and pathogenesis

Neeraj Vij et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2018)

Review Medicine, General & Internal

Asthma

Alberto Papi et al.

LANCET (2018)

Article Cell Biology

TORC1 inhibition enhances immune function and reduces infections in the elderly

Joan B. Mannick et al.

SCIENCE TRANSLATIONAL MEDICINE (2018)

Review Respiratory System

Autophagy, selective autophagy, and necroptosis in COPD

Kenji Mizumura et al.

INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (2018)

Article Medicine, Research & Experimental

mTOR pathway activation drives lung cell senescence and emphysema

Amal Houssaini et al.

JCI INSIGHT (2018)

Review Biochemistry & Molecular Biology

Monitoring and Measuring Autophagy

Saori R. Yoshii et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Review Biotechnology & Applied Microbiology

Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles

Lorenzo Galluzzi et al.

NATURE REVIEWS DRUG DISCOVERY (2017)

Article Multidisciplinary Sciences

Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages

W. K. Eddie Ip et al.

SCIENCE (2017)

Article Multidisciplinary Sciences

Suppression of Th17-polarized airway inflammation by rapamycin

Oana Joean et al.

SCIENTIFIC REPORTS (2017)

Review Cell Biology

Autophagy-monitoring and autophagy-deficient mice

Akiko Kuma et al.

AUTOPHAGY (2017)

Editorial Material Cell Biology

A new probe to measure autophagic flux in vitro and in vivo

Hideaki Morishita et al.

AUTOPHAGY (2017)

Article Cell Biology

IL13 activates autophagy to regulate secretion in airway epithelial cells

John D. Dickinson et al.

AUTOPHAGY (2016)

Article Critical Care Medicine

Restoration of Corticosteroid Sensitivity in Chronic Obstructive Pulmonary Disease by Inhibition of Mammalian Target of Rapamycin

Akihisa Mitani et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2016)

Article Allergy

Lack of autophagy induces steroid-resistant airway inflammation

Yuzo Suzuki et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2016)

Article Medicine, General & Internal

Association of autophagy related gene polymorphisms with neutrophilic airway inflammation in adult asthma

Duy Le Pham et al.

KOREAN JOURNAL OF INTERNAL MEDICINE (2016)

Review Biochemistry & Molecular Biology

AMPK activators: mechanisms of action and physiological activities

Joungmok Kim et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2016)

Article Biochemistry & Molecular Biology

The role of autophagy in allergic inflammation: a new target for severe asthma

Jing-Nan Liu et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2016)

Article Biochemistry & Molecular Biology

Role of Cigarette Smoke-Induced Aggresome Formation in Chronic Obstructive Pulmonary Disease-Emphysema Pathogenesis

Ian Tran et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2015)

Article Biochemistry & Molecular Biology

Alternaria extract activates autophagy that induces IL-18 release from airway epithelial cells

Hiroki Murai et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)

Article Critical Care Medicine

Simvastatin Suppresses Airway IL-17 and Upregulates IL-10 in Patients With Stable COPD

Kittipong Maneechotesuwan et al.

Article Medicine, General & Internal

Association of Egr-1 and autophagy-related gene polymorphism in men with chronic obstructive pulmonary disease

Chiung-Zuei Chen et al.

JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION (2015)

Article Biochemistry & Molecular Biology

Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates

Daniel F. Egan et al.

MOLECULAR CELL (2015)

Article Pharmacology & Pharmacy

Atorvastatin in combination with inhaled beclometasone modulates inflammatory sputum mediators in smokers with asthma

Neil C. Thomson et al.

PULMONARY PHARMACOLOGY & THERAPEUTICS (2015)

Article Medicine, General & Internal

Chronic obstructive pulmonary disease

Peter J. Barnes et al.

NATURE REVIEWS DISEASE PRIMERS (2015)

Article Medicine, Research & Experimental

Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD

Kenji Mizumura et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

Article Physiology

Mitochondrial fragmentation in cigarette smoke-induced bronchial epithelial cell senescence

Hiromichi Hara et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2013)

Article Medicine, Research & Experimental

Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction

Hilaire C. Lam et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Letter Medicine, General & Internal

Autophagy in Human Health and Disease REPLY

Augustine M. K. Choi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Review Medicine, General & Internal

MECHANISMS OF DISEASE Autophagy in Human Health and Disease

Augustine M. K. Choi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Physiology

Acute cigarette smoke exposure impairs proteasome function in the lung

Sabine H. van Rijt et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2012)

Article Physiology

TLR4 deficiency promotes autophagy during cigarette smoke-induced pulmonary emphysema

Chang Hyeok An et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2012)

Article Critical Care Medicine

Defective Phagocytosis in Airways Disease

Louise E. Donnelly et al.

Article Gastroenterology & Hepatology

Autophagy Releases Lipid That Promotes Fibrogenesis by Activated Hepatic Stellate Cells in Mice and in Human Tissues

Virginia Hernandez-Gea et al.

GASTROENTEROLOGY (2012)

Letter Allergy

Genetic and histologic evidence for autophagy in asthma pathogenesis

Audrey H. Poon et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2012)

Article Multidisciplinary Sciences

Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion

Teresa L. M. Thurston et al.

NATURE (2012)

Article Critical Care Medicine

Genome-wide Association Study Identifies BICD1 as a Susceptibility Gene for Emphysema

Xiangyang Kong et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2011)

Review Cell Biology

Selective autophagy mediated by autophagic adapter proteins

Terje Johansen et al.

AUTOPHAGY (2011)

Article Biochemistry & Molecular Biology

Inducible disruption of autophagy in the lung causes airway hyper-responsiveness

Daisuke Inoue et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)

Article Immunology

Identification of an Autophagy Defect in Smokers' Alveolar Macrophages

Martha M. Monick et al.

JOURNAL OF IMMUNOLOGY (2010)

Article Multidisciplinary Sciences

Autophagy protein microtubule-associated protein 1 light chain-3B (LC3B) activates extrinsic apoptosis during cigarette smoke-induced emphysema

Zhi-Hua Chen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Allergy

Sputum indoleamine-2, 3-dioxygenase activity is increased in asthmatic airways by using inhaled corticosteroids

Kittipong Maneechotesuwan et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2008)