期刊
CLINICAL NUTRITION
卷 41, 期 5, 页码 1122-1130出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.clnu.2022.03.020
关键词
Urinary bladder cancer; Tea; Smoking; Dose-response analysis; Cohort studies; Epidemiology
资金
- World Cancer Research Fund International [WCRF 2012/590]
- European Commission [FP7-PEOPLE-618308]
- Dutch Cancer Society
- US Department of Energy (DOE)
- DOE [DEHS0000031]
- RERF [RP-A5-12]
- National Cancer Institute [R01CA74846]
- Radiation Effects Research Foundation (RERF), Hiroshima and Nagasaki, Japan, a public interest foundation - Japanese Ministry of Health, Labour and Welfare (MHLW)
- Europe Against Cancer Programme of the European Commission (SANCO)
- Ligue contre le Cancer (France)
- Societe 3 M (France)
- Mutuelle Generale de l'Education Nationale
- Institut National de la Sante et de la Recherche Medicale (INSERM)
- Institute Gustave Roussy
- German Cancer Aid
- German Cancer Research Centre
- German Federal Ministry of Education and Research
- Danish Cancer Society
- Health Research Fund (FIS) of the Spanish Ministry of Health
- Spanish Regional Government of Andalucia
- Spanish Regional Government of Asturias
- Spanish Regional Government of Basque Country
- Spanish Regional Government of Murcia
- Spanish Regional Government of Navarra
- Cancer Research UK
- Medical Research Council, UK
- Stroke Association, UK
- British Heart Foundation
- Department of Health, UK
- Food Standards Agency, UK
- Wellcome Trust, UK
- Italian Association for Research on Cancer
- Italian National Research Council
- Dutch Ministry of Public Health, Welfare and Sports
- Dutch Prevention Funds
- LK Research Funds
- Dutch ZON (Zorg Onderzoek Nederland)
- World Cancer Research Fund
- Swedish Cancer Society
- Swedish Scientific Council
- Regional Government of Skane, Sweden
- Norwegian Cancer Society
- Norwegian Research Council
- Centre de Recherche etd'In-formation Nutritionnelles (CERIN)
Higher consumption of tea is associated with a reduced risk of bladder cancer, especially among men and smokers. Further studies are needed to clarify the mechanisms of the protective effect of tea and its interaction with smoking and sex.
Background & aims: Tea has been shown to be associated with reduced risk of several diseases including cardiovascular diseases, stroke, metabolic syndrome, and obesity. However, the results on the relation-ship between tea consumption and bladder cancer are conflicting. This research aimed to assess the association between tea consumption and risk of bladder cancer using a pooled analysis of prospective cohort data. Methods: Individual data from 532,949 participants in 12 cohort studies, were pooled for analyses. Cox regression models stratified by study centre was used to estimate hazard ratios (HR) and corresponding 95% CIs. Fractional polynomial regression models were used to examine the dose-response relationship. Results: A higher level of tea consumption was associated with lower risk of bladder cancer incidence (compared with no tea consumption: HR = 0.87, 95% C.I. = 0.77-0.98 for low consumption; HR = 0.86, 95% C.I. = 0.77-0.96 for moderate consumption; HR = 0.84, 95% C.I. = 0.75-0.95 for high consumption). When stratified by sex and smoking status, this reduced risk was statistically significant among men and current and former smokers. In addition, dose-response analyses showed a lower bladder cancer risk with increment of 100 ml of tea consumption per day (HR-increment = 0.97; 95% CI = 0.96-0.98). A similar inverse association was found among males, current and former smokers while never smokers and females showed non-significant results, suggesting potential sex-dependent effect. Conclusions: Higher consumption of tea is associated with reduced risk of bladder cancer with potential interaction with sex and smoking status. Further studies are needed to clarify the mechanisms for a protective effect of tea (e.g. inhibition of the survival and proliferation of cancer cells and antiinflammatory mechanisms) and its interaction with smoking and sex. (c) 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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