期刊
CLINICAL NEUROPHYSIOLOGY
卷 135, 期 -, 页码 37-50出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.clinph.2021.11.073
关键词
Electrical nerve stimulation; Electroencephalogram; Long-latency somatosensory evoked potentials; Trigeminal nerve; Transcranial magnetic stimulation; Dorsolateral prefrontal cortex
资金
- Marga und Walter Boll-Foundation [431549029 - SFB 1451]
- [210-03.03-18]
This study focused on the topography and lateralization of long-latency trigeminal somatosensory evoked potentials (SSEPs), comparing them with TMS-evoked potentials. The results showed a contralateral lateralization of the somatosensory N140 generated by trigeminal stimulation. Therefore, caution should be exercised when interpreting contralateral potentials after transcranial magnetic stimulation, as they may include somatosensory components.
Objective: Long-latency trigeminal somatosensory evoked potentials (SSEPs) have not been sufficiently studied regarding their topography and lateralization. SSEPs are hypothesized to contribute to the evoked potentials after transcranial magnetic stimulation (TMS). This study focused on trigeminal SSEPs with latencies > 100 ms, potentially overlapping with TMS-evoked N100. Methods: In 14 healthy subjects, the trigeminus was electrically stimulated on the left and right forehead, and time-course, topography, and lateralization of trigeminal SSEPs were examined in 64-channel electroencephalogram (EEG). SSEPs were then compared to TMS-evoked potentials when TMS was applied to the left and right dorsolateral prefrontal cortex. Results: Trigeminal stimulation produced a somatosensory N140 with topographic maximum over centroparietal electrodes with larger amplitudes contra- than ipsilaterally to the stimulation. Contralateral potentials after TMS were partly comparable in their topography but differed in latencies. Conclusions: SSEPs generated by electrical stimulation of the trigeminus occurred over somatosensory areas with a contralateral lateralization. Therefore, contralateral potentials after TMS should be interpreted with caution, as they may include somatosensory components. Significance: The topography and lateralization of long-latency trigeminal SSEPs should be considered in future TMS-EEG designs. (C) 2021 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.
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