Barques are generated in posterior hippocampus and phase reverse over lateral posterior hippocampal surface

Objective: To investigate whether barques can be localized across the hippocampal longitudinal axis with sufficient specificity. Methods: We identified 51 focal epilepsy patients implanted with a minimum of two electrodes - unilateral anterior and posterior -in either hippocampus. We used visual inspection of the intracranial electroencephalogram (iEEG) and 3D brain volume spectrum-based statistical parametric mapping (SPM) to localize barques. Results: In 18/51 patients (35.29%), barques were identified in 22/70 (31.42%) hippocampi. In all hippocampi (100%), barques were present in the posterior hippocampus, while 9 (40.90%) showed concurrent non-independent barque activity anteriorly (P < 0.0001). Statistical parametric mapping confirmed the posterior barque localization, with significant differences in t-values (t(27) = 8.08, P < 0.0001) and z-scores (t(24) = 6.85, P < 0.0001) between anterior and posterior hippocampal barque activity. Posterior lateral extrahippocampal contacts demonstrated phase reversals of positive polarity during barque activity (P = 0.0092, compared to anterior extrahippocampal contacts). Conclusions: This study highlights the posterior hippocampal predominance of barques. Our findings are concordant with the posterior distribution of the scalp manifestation of barques as 148:6/sec positive spikes . The posterio-lateral hippocampal barque phase reversal can explain the positive polarity of scalp 148:6/sec spikes. Significance: Understanding the properties of barques is critical for the iEEG interpretation in epilepsy surgery evaluations that include the hippocampus. (c) 2022 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.

Automated summary

This study investigates the localization of barques across the hippocampal longitudinal axis. By analyzing data from 51 epilepsy patients, the study found that barques predominantly occur in the posterior hippocampus and are related to barque activity in the anterior hippocampus. Statistical parametric mapping confirmed significant differences in barque activity between the anterior and posterior hippocampus. The findings have important implications for the interpretation of intracranial electroencephalogram in epilepsy surgery evaluations involving the hippocampus.