4.4 Article

Safety of Tepotinib in Patients With MET Exon 14 Skipping NSCLC and Recommendations for Management

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

Tepotinib Efficacy and Safety in Patients with MET Exon 14 Skipping NSCLC: Outcomes in Patient Subgroups from the VISION Study with Relevance for Clinical Practice

Xiuning Le et al.

Summary: Tepotinib demonstrated durable clinical activity in patients with METex14 skipping non-small cell lung cancer and consistent efficacy and manageable safety profile across different subgroups.

CLINICAL CANCER RESEARCH (2022)

Article Urology & Nephrology

Capmatinib-Induced Pseudo-Acute Kidney Injury: A Case Report

Arjunmohan Mohan et al.

Summary: This case illustrates that MET inhibitor therapy may lead to pseudo-acute kidney injury, with fluctuations in serum creatinine levels not necessarily reflecting changes in glomerular filtration rate. Accurate assessment of GFR is crucial for distinguishing AKI, avoiding unnecessary invasive tests, such as kidney biopsy, and premature discontinuation of cancer therapy.

AMERICAN JOURNAL OF KIDNEY DISEASES (2022)

Article Oncology

Therapy for Stage IV Non-Small-Cell Lung Cancer With Driver Alterations: ASCO and OH (CCO) Joint Guideline Update

Nasser H. Hanna et al.

Summary: The updated guidelines provide evidence-based recommendations for systemic therapy in stage IV NSCLC patients with driver alterations, based on systematic reviews of randomized controlled trials and meeting abstracts. These recommendations emphasize the importance of testing for targetable mutations before initiating therapy, and highlight the use of targeted therapies for specific alterations like ROS-1 fusions and BRAF V600e mutations.

JOURNAL OF CLINICAL ONCOLOGY (2021)

Article Oncology

Phase 1b/2 trial of tepotinib in sorafenibpretreated advanced hepatocellular carcinoma with MET overexpression

Thomas Decaens et al.

Summary: Tepotinib showed good tolerability and promising efficacy at the recommended dose of 500 mg in sorafenib-pretreated aHCC patients with MET overexpression.

BRITISH JOURNAL OF CANCER (2021)

Article Oncology

Randomised Phase 1b/2 trial of tepotinib vs sorafenib in Asian patients with advanced hepatocellular carcinoma with MET overexpression

Baek-Yeol Ryoo et al.

Summary: This study evaluated the efficacy of the MET inhibitor Tepotinib in Asian patients with aHCC, showing improved time to progression and better tolerability compared to sorafenib.

BRITISH JOURNAL OF CANCER (2021)

Article Critical Care Medicine

Once-daily savolitinib in Chinese patients with pulmonary sarcomatoid carcinomas and other non-small-cell lung cancers harbouring MET exon 14 skipping alterations: a multicentre, single-arm, open-label, phase 2 study

Shun Lu et al.

Summary: The study investigated the activity and safety of savolitinib in patients with pulmonary sarcomatoid carcinoma and other NSCLC subtypes positive for METex14 alterations. Results showed that savolitinib demonstrated promising activity and acceptable safety profile in these patients, suggesting it could be a novel treatment option for this population.

LANCET RESPIRATORY MEDICINE (2021)

Article Pharmacology & Pharmacy

Translational pharmacokinetic-pharmacodynamic modeling of preclinical and clinical data of the oral MET inhibitor tepotinib to determine the recommended phase II dose

Wenyuan Xiong et al.

Summary: Tepotinib is a highly selective and potent MET inhibitor for solid tumors, with dose selection based on translational modeling and efficacy-driven rationale. Preclinical data showed that tumor regression corresponds to 95% target inhibition, suggesting sustained, near-to-complete phospho-MET inhibition as the PD criterion for efficacy. Simulations in human tumors supported an RP2D of tepotinib 500 mg once daily, which has subsequently obtained regulatory approval for treating non-small cell lung cancer with MET exon 14 skipping.

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY (2021)

Article Biochemistry & Molecular Biology

Antitumor activity of crizotinib in lung cancers harboring a MET exon 14 alteration

Alexander Drilon et al.

NATURE MEDICINE (2020)

Article Medicine, General & Internal

Tepotinib in Non-Small-Cell Lung Cancer with MET Exon 14 Skipping Mutations

Paul K. Paik et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Medicine, General & Internal

Capmatinib in MET Exon 14-Mutated or MET-Amplified Non-Small-Cell Lung Cancer

Juergen Wolf et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Oncology

Phase I trial of the MET inhibitor tepotinib in Japanese patients with solid tumors

Kohei Shitara et al.

JAPANESE JOURNAL OF CLINICAL ONCOLOGY (2020)

Article Multidisciplinary Sciences

Effect of tyrosine kinase inhibitors on renal handling of creatinine by MATE1

Saki Omote et al.

SCIENTIFIC REPORTS (2018)

Review Respiratory System

Lung cancer and interstitial lung disease: a literature review

Jean-Marc Naccache et al.

JOURNAL OF THORACIC DISEASE (2018)

Editorial Material Oncology

Targeting ROS1 rearrangements in non-small cell lung cancer with crizotinib and other kinase inhibitors

Kartik Sehgal et al.

TRANSLATIONAL CANCER RESEARCH (2018)

Review Medicine, General & Internal

Drug-Induced Interstitial Lung Disease: A Systematic Review

Sarah Skeoch et al.

JOURNAL OF CLINICAL MEDICINE (2018)

Review Pharmacology & Pharmacy

Renal function monitoring in heart failure - what is the optimal frequency? A narrative review

Ahmed Al-Naher et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2018)

Article Multidisciplinary Sciences

Comprehensive molecular profiling of lung adenocarcinoma

Eric A. Collisson et al.

NATURE (2014)