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Letter
Infectious Diseases
Sara Tomassini et al.
JOURNAL OF INFECTION
(2021)
Editorial Material
Infectious Diseases
Akiko Iwasaki
LANCET INFECTIOUS DISEASES
(2021)
Review
Biochemistry & Molecular Biology
Alessandro Sette et al.
Summary: The adaptive immune system, consisting of B cells, CD4(+) T cells, and CD8(+) T cells, plays varying roles in different viral infections and vaccines. Studies are showing that CD4(+) T cells, CD8(+) T cells, and neutralizing antibodies all play a part in controlling SARS-CoV-2 in COVID-19 cases, emphasizing the importance of understanding adaptive immunity in combating the disease.
Article
Immunology
Zhongyan Lu et al.
Summary: The study found that SARS-CoV-2-specific antibodies and T cells could still be detected 12 months after infection, with higher frequencies of SARS-CoV-2-specific CD4 T cells and antibodies seen in severe cases at 12 months. Additionally, polyfunctional and cytotoxic T cells responsive to SARS-CoV-2 were identified even in participants with a wide spectrum of disease severity.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Alice Cho et al.
Summary: Infection with SARS-CoV-2 leads to evolving B cell responses over at least a year, while vaccination with mRNA vaccines results in high plasma neutralizing activity against various variants. Memory B cells from vaccinated individuals show increased neutralizing activity between prime and boost, but do not exhibit further expansion in potency or breadth.
Article
Medicine, General & Internal
Einav G. Levin et al.
Summary: A study in Israel revealed that waning immunity after receiving two doses of the BNT162b2 vaccine led to an increase in the incidence of SARS-CoV-2 infection. Levels of spike-binding IgG and neutralizing antibodies decreased more significantly in men, individuals aged 65 or older, and immunosuppressed individuals in a longitudinal study involving nearly 4000 healthcare workers.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Medicine, General & Internal
Hiam Chemaitelly et al.
Summary: In a study conducted in Qatar involving over 900,000 participants, vaccine effectiveness peaked at 77.5% in the first month after the second dose. However, it declined afterwards to as low as 20% in months 5 through 7 after vaccination, while protection against severe Covid-19 remained above 90% for at least 6 months.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Multidisciplinary Sciences
Barak Mizrahi et al.
Summary: The study indicates preliminary evidence of waning vaccine effectiveness of BNT162b2 among all age groups above 16, with a higher incidence of infection in those vaccinated earlier in 2021. Further investigation into long-term protection against different strains is warranted.
NATURE COMMUNICATIONS
(2021)
Review
Immunology
Emily Bettini et al.
Summary: To successfully protect against pathogen infection, a vaccine must trigger efficient adaptive immunity involving B and T cell responses. mRNA vaccines have become leaders in the race to develop an effective COVID-19 vaccine due to their rapid development capabilities and ability to induce robust adaptive immune responses.
Article
Medicine, General & Internal
Christian Holm Hansen et al.
Summary: The study investigated the protection against SARS-CoV-2 reinfection, with results showing an 80.5% protection rate for individuals previously infected. Even in the population aged 65 years and older, the protection rate against reinfection reached 47.1%, with no significant differences observed by gender or time since infection.
Editorial Material
Biochemistry & Molecular Biology
Florian Krammer
Article
Medicine, General & Internal
Yinon M. Bar-On et al.
Summary: After receiving a third dose of the BNT162b2 mRNA vaccine, Israeli residents aged 60 and above who had previously received two doses of the vaccine saw significantly lower rates of confirmed Covid-19 infection and severe illness compared to those who did not receive a booster shot, indicating the effectiveness of the booster dose in reducing infection and severe illness.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Mark W. Tenforde et al.
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
(2021)
Article
Cell Biology
Kristen W. Cohen et al.
Summary: The study reveals that COVID-19 patients have durable broad-based immune responses, including the continuous generation of antibodies, memory B cells, and polyfunctional T cells, which help to rapidly generate antibody responses against virus re-exposure or vaccination.
CELL REPORTS MEDICINE
(2021)
Article
Medicine, General & Internal
Tyler J. VanderWeele et al.
ANNALS OF INTERNAL MEDICINE
(2017)
