Enhanced Liver Fibrosis Score Stratifies Hepatocellular Carcinoma Risk in Patients With Hepatitis B Surface Antigen Seroclearance

In this prospective study involving 337 chronic hepatitis B patients who achieved spontaneous hepatitis B surface antigen (HBsAg) seroclearance (SC), serum enhanced liver fibrosis (ELF) before SC was associated with hepatocellular carcinoma (HCC) (hazard ratio 2.588), and ELF 97% reduction in risk of HCC development in patients with age SC >= 50 (n = 190).

Automated summary

This prospective study found that enhanced liver fibrosis (ELF) in chronic hepatitis B patients before spontaneous HBsAg seroclearance was associated with hepatocellular carcinoma (HCC). Furthermore, a 97% reduction in ELF was found to significantly decrease the risk of HCC development in patients aged 50 or above after spontaneous seroclearance.