Circulation of an Artemisinin-Resistant Malaria Lineage in a Traveler Returning from East Africa to France

A returned traveler to Uganda presented with a Plasmodium falciparum kelch13 A675V mutant infection that exhibited delayed clearance under artesunate therapy. Parasites were genetically related to recently reported Ugandan artemisinin-resistant A675V parasites. Adequate malaria prevention measures and clinical and genotypic surveillance are important tools to avoid and track artemisinin resistance.

Automated summary

A returned traveler in Uganda was infected with a Plasmodium falciparum parasite with the kelch13 A675V mutant gene, which showed delayed clearance under treatment with artesunate. The parasites were genetically related to previously reported Ugandan artemisinin-resistant parasites. Adequate malaria prevention measures and clinical and genotypic surveillance are crucial for avoiding and tracking artemisinin resistance.