Temporal Dynamics of Nasopharyngeal and Tracheal Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Cycle Thresholds in Coronavirus Disease 2019 (COVID-19) Patients With Tracheostomy

Article Immunology

Impact of Severe Acute Respiratory Syndrome Coronavirus 2 Viral Load on Risk of Intubation and Mortality Among Hospitalized Patients With Coronavirus Disease 2019

Reed Magleby et al.

Summary: This study found that the admission SARS-CoV-2 viral load among hospitalized patients with COVID-19 is independently associated with the risk of intubation and in-hospital mortality, with higher viral loads linked to increased mortality and intubation risk.

CLINICAL INFECTIOUS DISEASES (2021)

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Article Surgery

Percutaneous and Open Tracheostomy in Patients with COVID-19 Comparison and Outcomes of an Institutional Series in New York City

Sallie M. Long et al.

Summary: This study aimed to report the safety, efficacy, and early results of tracheostomy in COVID-19 patients. The study found that tracheostomy can help wean patients off mechanical ventilation and sedation. There were no significant differences in outcomes between percutaneous and open methods.

ANNALS OF SURGERY (2021)

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Review Otorhinolaryngology

Tracheotomy in COVID-19 Patients: A Systematic Review and Meta-analysis of Weaning, Decannulation, and Survival

Daniel A. Benito et al.

Summary: This systematic review and meta-analysis found that over half of COVID-19 patients who underwent tracheotomy were successfully weaned off mechanical ventilation, with approximately one third successfully decannulated. The pooled mortality rate in tracheotomized patients with COVID-19 was 13.1%.

OTOLARYNGOLOGY-HEAD AND NECK SURGERY (2021)

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Editorial Material Medicine, General & Internal

Persistent viral RNA shedding in COVID-19: Caution, not fear

Mario Plebani

EBIOMEDICINE (2021)

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Review Public, Environmental & Occupational Health

Characteristics of Viral Shedding Time in SARS-CoV-2 Infections: A Systematic Review and Meta-Analysis

Danying Yan et al.

Summary: The viral shedding time (VST) of SARS-CoV-2 varies among different demographic and clinical characteristics, with longer VSTs observed in symptomatic infections, infected adults, individuals with chronic diseases, and stool specimens.

FRONTIERS IN PUBLIC HEALTH (2021)

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Article Medicine, Research & Experimental

Percutaneous and Open Tracheostomy in Patients With COVID-19: The Weill Cornell Experience in New York City

Sallie M. Long et al.

Summary: This study aimed to investigate the long-term tracheostomy outcomes in patients with COVID-19, finding that the majority of patients were successfully weaned off mechanical ventilation, sedation, and decannulated after the procedure. The main complication was minor bleeding, and there were no deaths attributable to tracheostomy.

LARYNGOSCOPE (2021)

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Article Otorhinolaryngology

Quantifying Viral Particle Aerosolization Risk During Tracheostomy Surgery and Tracheostomy Care

Alexandra J. Berges et al.

Summary: This study found that tracheostomy surgery and care procedures generate significant aerosols, which increase the risk of airborne disease transmission to healthcare workers. Covering the tracheostomy with a heat moisture exchanger (HME) and a surgical mask can reduce aerosolization and lower the risk of viral transmission to healthcare workers.

JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY (2021)

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Article Public, Environmental & Occupational Health

Can the cycle threshold (Ct) value of RT-PCR test for SARS CoV2 predict infectivity among close contacts?

Soha Al Bayat et al.

Summary: This study examined the potential infectivity among close contacts of COVID-19 positive cases with a cut off Ct value of 30. Results showed a significant relation between Ct value cut-off 30 and secondary transmission, with those having Ct value < 30 at 1.5 times higher risk. Further research combining PCR assays, culture studies, and contact tracing is needed to reliably predict the infectious status of COVID-19 patients.

JOURNAL OF INFECTION AND PUBLIC HEALTH (2021)

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Article Infectious Diseases

Viral RNA load as determined by cell culture as a management tool for discharge of SARS-CoV-2 patients from infectious disease wards

Bernard La Scola et al.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2020)

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Temporal Dynamics of Nasopharyngeal and Tracheal Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Cycle Thresholds in Coronavirus Disease 2019 (COVID-19) Patients With Tracheostomy

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