Coronavirus Disease 2019 Vaccine Trials (and Tribulations): How to Improve the Process of Clinical Trials in a Pandemic

Vaccine clinical trials were essential to developing effective severe acute respiratory syndrome coronavirus 2 vaccines. The challenges of supply chain disruptions, infection control, study designs, and participant factors are reviewed, along with ways to streamline the clinical trial process. Vaccine clinical trials have been essential to developing effective severe acute respiratory syndrome coronavirus 2 vaccines. The challenges of supply chain disruptions, infection control, study designs, and participant factors that affect trial procedures are reviewed, with specific solutions to streamline the clinical trial process.

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This article reviews the importance of vaccine clinical trials in developing effective COVID-19 vaccines. It highlights the challenges of supply chain disruptions, infection control, study designs, and participant factors, as well as specific solutions to streamline the clinical trial process.