期刊
CLINICAL INFECTIOUS DISEASES
卷 75, 期 10, 页码 1820-1826出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/ciac236
关键词
tuberculosis; recurrent tuberculosis; microbial translocation
资金
- Government of India's (GOI) Department of Biotechnology (DBT)
- Indian Council of Medical Research (ICMR)
- US National Institutes of Health (NIH)
- National Institute of Allergy and Infectious Diseases (NIAID), Office of AIDS Research (OAR)
- CRDF Global [USB1-31149-XX-13]
- CRDF Global RePORT India Consortium Supplementary Funding [OISE-17-62911-1]
- Division of Intramural Research, NIAID, NIH
This study found that microbial translocation is closely associated with recurrence in pulmonary tuberculosis (PTB). Within a year after treatment, levels of lipopolysaccharide (LPS), sCD14, and LPS-binding protein (LBP) were significantly higher in the recurrence group compared to the control group, and were associated with increased risk for recurrence. These microbial markers can be used as a rapid prognostic tool for predicting recurrence in PTB.
Background. Microbial translocation is a known characteristic of pulmonary tuberculosis (PTB). Whether microbial translocation is also a biomarker of recurrence in PTB is not known. Methods. We examined the presence of microbial translocation in a cohort of newly diagnosed, sputum smear, and culture positive individuals with drug-sensitive PTB. Participants were followed up for a year following the end of anti-tuberculosis treatment. They were classified as cases (in the event of recurrence, n = 30) and compared to age and gender matched controls (in the event of successful, recurrence free cure; n = 51). Plasma samples were used to measure the circulating microbial translocation markers. All the enrolled study participants were treatment naive, HIV negative and with or without diabetes mellitus. Results. Baseline levels of lipopolysaccharide (LPS) (P = .0002), sCD14 (P = .0191), and LPS-binding protein (LBP) (P < .0001) were significantly higher in recurrence than controls and were associated with increased risk for recurrence, whereas intestinal fatty acid binding protein (I-FABP) and Endocab showed no association. Receiver operating characteristic (ROC) curve analysis demonstrated the utility of these individual microbial markers in discriminating recurrence from cure with high sensitivity, specificity, and area under the curve (AUC). Conclusions. Recurrence following microbiological cure in PTB is characterized by heightened baseline microbial translocation. These markers can be used as a rapid prognostic tool for predicting recurrence in PTB.
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