期刊
CLINICAL IMMUNOLOGY
卷 236, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2022.108951
关键词
Dyserythropoietic anemia; Synartesis; Reticulocytopenia; Lymphoproliferative diseases; Monoclonal gammopathy
类别
Erythroblastic synartesis is a rare cause of acquired dyserythropoiesis, which can be associated with monoclonal immunoglobulin and malignant lymphoid disorder. Treatment targeting the paraprotein seems to be efficient in controlling synartesis and correcting anemia.
Erythroblastic synartesis is a rare cause of acquired dyserythropoiesis. Only 9 cases have been previously reported. We hereby report 3 cases of patients diagnosed with erythroblastic synartesis associated with monoclonal immunoglobulin and an overt malignant lymphoid disorder. A different B-cell clone may produce the monoclonal immunoglobulin, forming a biclonal disorder. In light of these data and literature review, treatment targeting the paraprotein seems to be efficient to control synartesis and correct anemia. In the case of monoclonal gammapathy associated with chronic lymphocytic leukemia, therapeutics should be adapted to control both chronic lymphocytic leukemia and monitored monoclonal immunoglobulin titer.
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