期刊
CLINICAL IMMUNOLOGY
卷 237, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2022.108987
关键词
SLE; Lupus nephritis; B cells; T cells
类别
资金
- National Natural Science Foundation of China [81671629, 82171724, 82171784]
- Natural Science foundation of Shaanxi Province [2021JQ-393]
SLC7A5 expression is increased in CD4+ T cells and CD19+ B cells of SLE patients, and this up-regulation is positively correlated with kidney function. SLC7A5 may play a potential role in mediating renal damage in SLE.
Metabolic reprogramming of immune cells has been proven to be important for systemic lupus erythematosus (SLE). This study aims to understand the role of SLC7A5, an amino acid transporter, in SLE. We analyzed SLC7A5 mRNA expression of SLE patients compared to healthy controls using GEO database, and found that it was increased in CD4+ T cells and CD19+ B cells. We then confirmed the expression up-regulation using flow cytometry and found that the proportion of SLC7A5+ cells and its expression were increased in peripheral blood T and B cells from SLE patients. Importantly, SLC7A5 expression in T and B cells was positively correlated with blood urea nitrogen and serum creatinine. Therefore, we conclude that SLC7A5, up-regulating in circulating T and B cells, correlates with kidney function, suggesting its potential role in mediating renal damage in SLE, which provides novel insight into SLE pathogenesis and provides a potential biomarker for disease.
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