4.7 Editorial Material

Standing Watch: Immune Activation and Failure in Melanoma Sentinel Lymph Nodes

期刊

CLINICAL CANCER RESEARCH
卷 28, 期 10, 页码 1996-1998

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AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1078-0432.CCR-22-0214

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  1. NIH/NCI [R01 CA238163]
  2. American Cancer Society [RSG-18-169-01]
  3. Cancer Research Institute Lloyd J. Old STAR Award
  4. Mark Foundation for Cancer Research Emerging Leader Award

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An objective approach was used to study the sentinel lymph node landscape in patients with stage I-III cutaneous melanoma, revealing that micrometastasis is associated with progressive immune dysfunction. Tumor-induced lymph node dysfunction may lead to new hypotheses for neoadjuvant therapy that aims to reinvigorate the body's own anti-tumor immunity.
An unbiased approach to map the sentinel lymph node landscape reveals progressive immune dysfunction associated with micrometastasis in patients with stage I-III cutaneous melanoma. Evidence of tumor-induced lymph node dysfunction may motivate new hypotheses for neoadjuvant therapy with potential to reinvigorate endogenous antitumor immunity.

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