期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 84, 期 -, 页码 188-197出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2014.09.008
关键词
Muscle regeneration; Satellite cell; Synthetic niche; Microenvironmental cue; Tissue engineered muscle; Cell therapy; Drug delivery
资金
- NIDCR NIH HHS [R01 DE013349] Funding Source: Medline
Skeletal muscle possesses a remarkable capacity for regeneration in response to minor damage, but severe injury resulting in a volumetric muscle loss can lead to extensive and irreversible fibrosis, scarring, and loss of muscle function. In early clinical trials, the intramuscular injection of cultured myoblasts was proven to be a safe but ineffective cell therapy, likely due to rapid death, poor migration, and immune rejection of the injected cells. In recent years, appropriate therapeutic cell types and culturing techniques have improved progenitor cell engraftment upon transplantation. Importantly, the identification of several key biophysical and biochemical cues that synergistically regulate satellite cell fate has paved the way for the development of cell-instructive biomaterials that serve as delivery vehicles for cells to promote in vivo regeneration. Material carriers designed to spatially and temporally mimic the satellite cell niche may be of particular importance for the complete regeneration of severely damaged skeletal muscle. (C) 2014 Elsevier B.V. All rights reserved.
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