期刊
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
卷 208, 期 2, 页码 193-201出版社
OXFORD UNIV PRESS
DOI: 10.1093/cei/uxac048
关键词
dendritic cells; metabolism; vaccines; antitumour immunity
类别
资金
- European research council [ERC-CoG 770769]
This review discusses the critical role of dendritic cell metabolism in vaccine formulation and explores opportunities to improve vaccine effectiveness through metabolic pathways.
The critical role developed by dendritic cell (DC) in the orchestration of immune response explains its exploitation in different therapeutic approaches as potential vaccine tools. Various clinical trials dissect its role in different types of solid cancers. However, there is a lack of comprehension regarding the potential impact of DC metabolic pathways on the effectiveness of DC vaccine. In this review, we intend to dissect how metabolism could be a critical component of DC vaccine formulation, exploring opportunities to improve: (i) processing and cross-presentation of tumour antigens; (ii) DC migration, and (iii) DC immunogenic profile. Overall, we aim to open the discussion to explore new avenues/paths where DC metabolism might be considered a core component of antitumour DC vaccine with this review.
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