Effects of YM155 on the proliferation and apoptosis of pulmonary artery smooth muscle cells in a rat model of high pulmonary blood flow-induced pulmonary arterial hypertension

Article

Evaluation and Management of Pulmonary Arterial Hypertension in Congenital Heart Disease

Hassaan B Arshad et al.

Methodist DeBakey cardiovascular journal (2021)

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Review Medicine, General & Internal

Pulmonary Arterial Hypertension

Paul M. Hassoun

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Critical Care Medicine

Pulmonary Arterial Hypertension: Diagnosis, Treatment, and Novel Advances

Bradley A. Maron et al.

Summary: The diagnosis and management of pulmonary arterial hypertension have seen advances in early diagnosis, multiple pharmacotherapeutics, and new risk factors becoming focal points. Developmental biology may be useful in predicting incident PAH.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2021)

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Article Oncology

The prognostic significance of survivin expression in patients with HNSCC: a systematic review and meta-analysis

Liu-qing Zhou et al.

Summary: Our comprehensive meta-analysis revealed that survivin expression is significantly correlated with poorer overall survival and disease-free survival/disease-specific survival in HNSCC patients. Additionally, survivin is a potential therapeutic target for HNSCC.

BMC CANCER (2021)

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Article Pharmacology & Pharmacy

Sanguinarine Reverses Pulmonary Vascular Remolding of Hypoxia-Induced PH via Survivin/HIF1α-Attenuating Kv Channels

Fenling Fan et al.

Summary: The study demonstrates that sanguinarine can effectively alleviate pulmonary vascular remodeling and cell proliferation caused by hypoxic pulmonary hypertension, possibly through regulating the survivin pathway and ion channels.

FRONTIERS IN PHARMACOLOGY (2021)

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Review Biotechnology & Applied Microbiology

Survivin as a biological biomarker for diagnosis and therapy

Yuming Li et al.

Summary: Survivin is a protein that promotes cellular proliferation and inhibits apoptosis, with its overexpression associated with autoimmune diseases, hyperplasia, and tumors, making it a potential biomarker. It is widely recognized as a tumor-associated antigen and is being used in cancer diagnosis and treatment. The most promising developments involve anti-SVN immunotherapy, with several therapeutic SVN vaccines under evaluation in phase I/II trials.

EXPERT OPINION ON BIOLOGICAL THERAPY (2021)

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Article Pharmacology & Pharmacy

Role of Survivin in Bladder Cancer: Issues to Be Overcome When Designing an Efficient Dual Nano-Therapy

Maria Arista-Romero et al.

Summary: The dual nano-treatment for bladder cancer based on survivin inhibition and paclitaxel did not show the expected synergistic effect, possibly due to cell cycle arrest caused by nuclear survivin silencing, which is incompatible with the action of paclitaxel.

PHARMACEUTICS (2021)

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Review Medicine, General & Internal

Vascular Remodeling in Pulmonary Arterial Hypertension: The Potential Involvement of Innate and Adaptive Immunity

Rachid Tobal et al.

Summary: PAH is a severe disease with high morbidity and mortality. Recent literature has highlighted the important interaction between immune cells and stromal vascular cells in the pathogenic modifications of the pulmonary vasculature, leading to vascular remodeling, increased pulmonary vascular resistance, and eventually PAH. Understanding the underlying immunological mechanisms may be key to halting disease progression.

FRONTIERS IN MEDICINE (2021)

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Article Cell Biology

LncRNA PAXIP1-AS1 fosters the pathogenesis of pulmonary arterial hypertension via ETS1/WIPF1/RhoA axis

Rong Song et al.

Summary: The study found that lncRNA PAXIP1-AS1 promotes cell viability and migration of hPASMCs through ETS1/WIPF1/RhoA, potentially providing a therapeutic target for PAH treatment.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Review Oncology

Kidney cancer biomarkers and targets for therapeutics: survivin (BIRC5), XIAP, MCL-1, HIF1α, HIF2α, NRF2, MDM2, MDM4, p53, KRAS and AKT in renal cell carcinoma

Fengzhi Li et al.

Summary: Renal cell carcinoma (RCC) is on the rise globally with a challenging therapy-resistance due to multiple genetic and epigenetic alterations. Various proteins like survivin, HIF, NRF2, MDM2, and KRAS are believed to be potential therapeutic biomarkers and targets for treatment resistance.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

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Review Cell Biology

Role of Long Non-Coding RNAs in Pulmonary Arterial Hypertension

Yun Han et al.

Summary: Pulmonary arterial hypertension (PAH) is a debilitating condition that, if untreated, can lead to right heart failure and death. Despite existing treatment options, the disease is incurable, and there is an urgent need for novel therapies. Long non-coding RNAs (lncRNAs) play critical roles in the pathogenesis of PAH by affecting pulmonary vascular remodeling and endothelial dysfunction.

CELLS (2021)

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Review Oncology

Prognostic Value of Survivin in Nasopharyngeal Carcinoma: A Systematic Review and Meta-analysis

Wenji Xie et al.

Summary: The meta-analysis shows that survivin expression is associated with poor overall survival, lymph node metastasis, local recurrence, distant metastasis, and a higher clinical stage in nasopharyngeal carcinoma, suggesting its potential as a biomarker for predicting prognosis.

JOURNAL OF CANCER (2021)

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Review Cell Biology

The survivin molecule as a double-edged sword in cellular physiologic and pathologic conditions and its role as a potential biomarker and therapeutic target in cancer

Atieh Rafatmanesh et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2020)

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Review Cardiac & Cardiovascular Systems

Pathobiology of pulmonary artery hypertension: role of long non-coding RNAs

Kashif Rafiq Zahid et al.

CARDIOVASCULAR RESEARCH (2020)

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Article Otorhinolaryngology

Restoring apoptosis dysregulation using survivin inhibitor in nasopharyngeal cancer

Junli Shi et al.

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK (2020)

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Article Medicine, Research & Experimental

Modeling of Hypervolemia in Pulmonary Circulation in Rats Changes the Structure of NO-Mediated Relaxation of Pulmonary Arteries

M. P. Davydova

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE (2020)

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Article Oncology

YM155 Reverses Cabazitaxel Resistance in Castration-resistant Prostate Cancer by Reducing Survivin Expression

Takeshi Miyao et al.

ANTICANCER RESEARCH (2020)

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Review Pediatrics

Pediatric Pulmonary Arterial Hypertension

Benjamin S. Frank et al.

PEDIATRIC CLINICS OF NORTH AMERICA (2020)

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Article Pharmacology & Pharmacy

Emerging Effects of Sepantronium Bromide (YM155) on MOLT-4 Cell Line Apoptosis Induction and Expression of Critical Genes Involved in Apoptotic Pathways

Kobra Shojaei Moghadam et al.

ADVANCED PHARMACEUTICAL BULLETIN (2020)

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Review Cell Biology

Anti-apoptotic proteins in the autophagic world: an update on functions of XIAP, Survivin, and BRUCE

Chun Hei Antonio Cheung et al.

JOURNAL OF BIOMEDICAL SCIENCE (2020)

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Review Oncology

Survivin overexpression in head and neck squamous cell carcinomas as a new therapeutic target

M. A. Frassanito et al.

ONCOLOGY REPORTS (2019)

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Article Multidisciplinary Sciences

The Left Pneumonectomy Combined with Monocrotaline or Sugen as a Model of Pulmonary Hypertension in Rats

Michael G. Katz et al.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2019)

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Review Cell Biology

Survivin a pivotal antiapoptotic protein in rheumatoid arthritis

Parisa Zafari et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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Article Biochemistry & Molecular Biology

Focus on Early Events: Pathogenesis of Pulmonary Arterial Hypertension Development

Olga Rafikova et al.

ANTIOXIDANTS & REDOX SIGNALING (2019)

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Article Biochemistry & Molecular Biology

Sepantronium Bromide (YM155), A Small Molecule Survivin Inhibitor, Promotes Apoptosis by Induction of Oxidative Stress, Worsens the Behavioral Deficits and Develops an Early Model of Toxic Demyelination: In Vivo and In-Silico Study

Samaneh Reiszadeh-Jahromi et al.

NEUROCHEMICAL RESEARCH (2019)

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Article Multidisciplinary Sciences

d-a-Tocopheryl Polyethylene Glycol 1000 Succinate and a small-molecule Survivin suppressant synergistically induce apoptosis in SKBR3 breast cancer cells

Christiana M. Neophytou et al.

SCIENTIFIC REPORTS (2019)

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Review Pathology

Survivin as a diagnostic and therapeutic marker for thyroid cancer

Mohammad-Reza Mahmoudian-Sani et al.

PATHOLOGY RESEARCH AND PRACTICE (2019)

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Review Cardiac & Cardiovascular Systems

Congenital Heart Disease and Neurodevelopment: Clinical Manifestations, Genetics, Mechanisms, and Implications

Sarah N. Nattel et al.

CANADIAN JOURNAL OF CARDIOLOGY (2017)

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Article Pharmacology & Pharmacy

YM155, a selective survivin inhibitor, reverses chronic hypoxic pulmonary hypertension in rats via upregulating voltage-gated potassium channels

Zaiwen Fan et al.

CLINICAL AND EXPERIMENTAL HYPERTENSION (2015)

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Review Cell Biology

Survivin - The inconvenient IAP

Dario C. Altieri

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2015)

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Article Biochemistry & Molecular Biology

Inhibitory effect of survivin-targeting small interfering RNA on gastric cancer cells

Y. H. Li et al.

GENETICS AND MOLECULAR RESEARCH (2014)

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Article Biochemical Research Methods

Interleukin Enhancer-binding Factor 3/NF110 Is a Target of YM155, a Suppressant of Survivin

Naoto Nakamura et al.

MOLECULAR & CELLULAR PROTEOMICS (2012)

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Article Physiology

Gene expression profile in flow-associated pulmonary arterial hypertension with neointimal lesions

Mirjam E. van Albada et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2010)

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Review Biotechnology & Applied Microbiology

Novel Approaches to Treat Experimental Pulmonary Arterial Hypertension: A Review

S. Umar et al.

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY (2010)

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Review Cardiac & Cardiovascular Systems

Pathogenic mechanisms of pulmonary arterial hypertension

Stephen Y. Chan et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2008)

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Article Cardiac & Cardiovascular Systems

Treprostinil in advanced experimental pulmonary hypertension: Beneficial outcome without reversed pulmonary vascular remodeling

Mirjam E. van Albada et al.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2006)

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Article Respiratory System

The role of increased pulmonary blood flow in pulmonary arterial hypertension

ME van Albada et al.

EUROPEAN RESPIRATORY JOURNAL (2005)

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Article Biochemistry & Molecular Biology

Inhibition of Wnt-2-mediated signaling induces programmed cell death in non-small-cell lung cancer cells

L You et al.

ONCOGENE (2004)

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Article Critical Care Medicine

Effect of a surgical aortocaval fistula on mono crotaline-induced pulmonary hypertension

T Nishimura et al.

CRITICAL CARE MEDICINE (2003)

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Effects of YM155 on the proliferation and apoptosis of pulmonary artery smooth muscle cells in a rat model of high pulmonary blood flow-induced pulmonary arterial hypertension

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