期刊
CLINICAL AND EXPERIMENTAL ALLERGY
卷 52, 期 5, 页码 684-696出版社
WILEY
DOI: 10.1111/cea.14117
关键词
16S rRNA; allergic disorders; atopic eczema; cow's milk allergy
资金
- Finnish Medical Foundation
- Pediatric Research Foundation
- Foundation for Pediatric Research
- Emil Aaltonen Foundation
- Alma and K. A. Snellman Foundation, Oulu, Finland
- Academy of Finland
Results from a prospective birth cohort study showed no association between the bacterial composition of the first-pass meconium and the development of allergic diseases before 4 years of age. However, larger studies are needed to fully exclude a relationship.
Background Some cohort studies have suggested that gut microbiota composition is associated with allergic diseases in children. The microbiota of the first-pass meconium, which forms before birth, represents the first gut microbiota that is easily available for research and little is known about any relationship with allergic disease development. Objective We investigated whether the bacterial composition of the first-pass meconium is associated with the development of allergic diseases before 4 years of age. Methods Prospective birth cohort study. Bacterial composition of first-pass meconium was analysed using bacterial 16S rRNA gene amplicon sequencing. Atopic and allergic diseases were evaluated via online survey or telephone to age 4 years, based on the International Study of Asthma and Allergies in Childhood questionnaire. Results During a 6-week period in 2014, 312 children were born at the Central Finland Central Hospital. Meconium was collected from 212 at a mean of 8-hour age. Outcome data at 4 years were available for 177 (83%) children, and 159 of these had sufficient amplification of bacterial DNA in meconium. Meconium microbiota composition, including diversity indices and relative abundances of the main phyla and genera, was not associated with subsequent atopic eczema, wheezing or cow's milk allergy. Principal components analysis did not identify any clustering of the meconium microbiomes of children with respect to wheezing or cow's milk allergy. Conclusions We found no evidence that gut microbiota composition of first-pass meconium is associated with atopic manifestations to age 4 years. However, larger studies are needed to fully exclude a relationship.
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