期刊
CLINICA CHIMICA ACTA
卷 531, 期 -, 页码 177-182出版社
ELSEVIER
DOI: 10.1016/j.cca.2022.04.003
关键词
cGAS; STING; Cell death; Ischemia; Reperfusion
资金
- Hunan Provincial Natural Science Foundation [2019JJ40248]
- Hunan Science and Technology Inno-vation Plan Project [2020SK51824]
- National Natural Sciences Foundation of China [81770490]
- Key Laboratory for Arteriosclerology of Hunan Province
Double stranded DNA (dsDNA) acts as a damage-associated molecular pattern (DAMP) that triggers the body's innate immune response. The cGAS-STING pathway is involved in cell death and is closely associated with the stimulation of self-DNA and autoimmune responses. This study provides an overview of the pathway's role in ischemia or ischemia/reperfusion studies in various organs.
Double stranded DNA (dsDNA) is known to act as a damage-associated molecular pattern (DAMP) that stimulates the body's innate immune response. In general, cyclic GMP-AMP (cGAMP) synthase (cGAS), a DNA sensor, detects these disease-causing DNA and activates the stimulator of interferon gene (STING), which in turn phosphorylates interferon regulatory factor 3 (IRF3), triggering the synthesis of type I interferon (IFN). During this process, the cGAS-STING pathway interacts with different modes of cell death, including autophagy, apoptosis, pyroptosis, and necroptosis. Importantly, cGAS might get stimulated by self-DNA, such as nuclear DNA (nuDNA) and mitochondrial DNA (mtDNA), which ensures a close association between the cGAS-STING signaling pathway and autoimmune responses. Following an ischemic attack, damaged or necrotic cells release large amounts of self-DNA that subsequently activate cGAS, resulting in a range of consequences related to an injury. The present study presents an overview of studies focused on cGAS-STING signaling and cell death, and summarizes the findings of this pathway with regard to ischemia or ischemia/reperfusion (I/R) in different organs of the body, including heart, brain, liver, kidney, and intestine.
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