4.7 Article

Unexpectedly low hemoglobin A1c in a patient with chronic lymphocytic leukemia

期刊

CLINICA CHIMICA ACTA
卷 531, 期 -, 页码 91-93

出版社

ELSEVIER
DOI: 10.1016/j.cca.2022.03.012

关键词

Hemoglobin A1c; Chronic lymphocytic leukemia; Interference; Enzymatic testing

向作者/读者索取更多资源

Glycated hemoglobin (HbA1c) assays are commonly used to monitor patients with type 2 diabetes, but enzymatic assays may be prone to interference from neoplastic lymphocytes, leading to inaccurate results. Awareness of this possibility and further investigation are necessary.
Glycated hemoglobin (HbA1c) assays are currently utilized to monitor patients with diabetes mellitus type 2 (T2DM). These assays employ various methods, some of which are more prone to interference than others. Commonly recognized causes of interference include hemoglobin variants and conditions that result in reduced red blood cell survival such as hemolytic anemia and certain medications. Enzymatic assays represent one of the predominant methods for HbA1c testing for practical reasons. Herein, we describe a potentially novel interference in an enzymatic HbA1c assay by neoplastic lymphocytes in a patient with chronic lymphocytic leukemia. We hypothesize that the marked number of neoplastic lymphocytes are interfering in the enzymatic steps inherent to this assay, resulting in a discordantly low HbA1c result. Awareness of this possibility and further investigation into the precise mechanism by which this interference is occurring are warranted.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据