期刊
CIRCULATION-CARDIOVASCULAR IMAGING
卷 15, 期 3, 页码 -出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCIMAGING.121.013348
关键词
atherosclerosis; computed tomography angiography; coronary angiography; coronary artery disease; prevalence
资金
- EASD
- new national excellence program of the ministry for innovation and technology from the national research, development, and innovation fund [UNKP-21-4-I-SE]
- National Heart Program [NVKP_16-1-2016-0017]
- National Research, Development and Innovation Fund of Hungary, under the NVKP_16 funding scheme
- Thematic Excellence Programme of the Ministry for Innovation and Technology in Hungary of the Semmelweis University [2020-4.1.1.-TKP2020]
This study found that noncalcified plaque volume is mainly influenced by environmental factors, while coronary artery calcification score and calcified plaque volume are more determined by genetics. This emphasizes the importance of early lifestyle interventions in preventing coronary plaque formation.
BACKGROUND: Genetics have a strong influence on calcified atherosclerotic plaques; however, data regarding the heritability of noncalcified plaque volume are scarce. We aimed to evaluate genetic versus environmental influences on calcium (coronary artery calcification) score, noncalcified and calcified plaque volumes by coronary computed tomography angiography in adult twin pairs without known coronary artery disease. METHODS: In the prospective BUDAPEST-GLOBAL (Burden of Atherosclerotic Plaques Study in Twins-Genetic Loci and the Burden of Atherosclerotic Lesions) classical twin study, we analyzed twin pairs without known coronary artery disease. All twins underwent coronary computed tomography angiography to assess coronary atherosclerotic plaque volumes. Structural equation models were used to quantify the contribution of additive genetic, common environmental, and unique environmental components to plaque volumes adjusted for age, gender, or atherosclerotic cardiovascular disease risk estimate and statin use. RESULTS: We included 196 twins (mean age +/- SD, 56 +/- 9 years, 63.3% females), 120 monozygotic and 76 same-gender dizygotic pairs. Using structural equation models, noncalcified plaque volume was predominantly determined by environmental factors (common environment, 63% [95% CI, 56%-67%], unique environment, 37% [95% CI, 33%-44%]), while coronary artery calcification score and calcified plaque volumes had a relatively strong genetic heritability (additive genetic, 58% [95% CI, 50%-66%]; unique environmental, 42% [95% CI, 34%-50%] and additive genetic, 78% [95% CI, 73%-80%]; unique environmental, 22% [95% CI, 20%-27%]), respectively. CONCLUSIONS: Noncalcified plaque volume is mainly influenced by shared environmental factors, whereas coronary artery calcification score and calcified plaque volume are more determined by genetics. These findings emphasize the importance of early lifestyle interventions in preventing coronary plaque formation.
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