期刊
CHROMOSOME RESEARCH
卷 30, 期 2-3, 页码 151-164出版社
SPRINGER
DOI: 10.1007/s10577-022-09695-4
关键词
t complex; gene drive; selfish genetic element; transmission ratio distortion; sperm motility; competition; social evolution
资金
- University of Zurich - Swiss National Science Foundation [31003A_160328]
- Swiss National Science Foundation (SNF) [31003A_160328] Funding Source: Swiss National Science Foundation (SNF)
The meiotic driver t haplotype causes lasting damage to the motility of both + and t developing sperm in mice, leading to a lower success rate in competition with +/+ sperm.
The ability to subvert independent assortment of chromosomes is found in many meiotic drivers, such as the t haplotype in house mice Mus musculus, in which the t-bearing chromosomal homolog is preferentially transmitted to offspring. This is explained by a poison-antidote system, in which developing + and t sperm in testes of + /t males are exposed to 'poison' coded by t loci, from which t sperm are protected, allowing t sperm an overwhelming fertilisation advantage in monogamous matings. This system is thought to result in poorly and normally motile sperm subpopulations within + /t sperm, leaving t sperm unharmed. Conversely, we found that the fastest quartile of sperm from + /t males swam more slowly, both forwards and along their travel path, and had reduced straightness and linearity, compared to the fastest quartile of + / + sperm. Moreover, sperm from + /t males had shorter tails and narrower heads than + / + sperm, and these morphological differences covaried with motility differences. Finally, + /t traits did not show evidence of bimodal distributions. We conclude that the t haplotype drive results in lasting damage to the motility of both + and t developing sperm, although previous studies indicate that + must be more harmed than t sperm. This damage to all sperm may explain the low success of + /t males in sperm competition with + / + males, seen in earlier studies. We propose that the harm the t causes to itself could be termed 'spiteful', which may also be common to other gamete-harming meiotic drive systems.
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