期刊
CHIRALITY
卷 34, 期 7, 页码 925-940出版社
WILEY
DOI: 10.1002/chir.23446
关键词
comparison between coated type and immobilized type; complementary properties and solvent resistance; enantiomer resolution by HPLC; immobilized polysaccharide-based chiral stationary phases
This study compares the chiral recognition abilities of different immobilized CSPs under normal phase liquid chromatography conditions. It finds that CHIRALPAK IG shows notable chiral recognition abilities and durability, with improved chiral separation selectivities for various racemates.
To date, various immobilized chiral stationary phases (CSPs) have been developed. The immobilized CSPs have opened up possibilities not only maintaining the high chiral recognition abilities as well as corresponding coated ones but also affording high durability to various mobile phase. This report directed to investigate enantioseparation of recently launched four immobilized CSPs with cellulose and amylose backbones under normal phase liquid chromatography conditions. Their chiral recognition abilities were compared with previously developed six immobilized CSPs. Particularly, we focused on the complementarity for chiral recognitions. Among them, amylose tris(3-chloro-5-methylphenylcarbamate) CSP, namely, CHIRALPAK IG, showed notable chiral recognition abilities to various racemates. As expected, the investigated immobilized CSPs represented remarkable durability to wide range of mobile phases, whereas the corresponding coated CSPs could not be run due to the irreversible degradation. Taking advantage of unrestricted solvent compatibility, chiral separation selectivities were improved for some racemates.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据