4.5 Review

Structural and Biological Insights into the Hot-Spot Marine Natural Products Reported from 2012 to 2021

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Article Chemistry, Applied

Terpenoids from the South China Sea soft coral Sinularia multiflora

Zheng Wang et al.

Summary: Two new compounds, Sinulariadiolide B and Multifloralin, were isolated from the South China Sea soft coral, with unique structures and potent antifouling activity against barnacles. The structures were elucidated through detailed spectroscopic analysis and comparison with known data.

NATURAL PRODUCT RESEARCH (2021)

Article Plant Sciences

Strepyrazinone, a tricyclic diketopiperazine derivative with cytotoxicity from a marine-derived actinobacterium

Lu Zhang et al.

Summary: Strepyrazinone (1), a novel tricyclic diketopiperazine derivative with an unprecedented carbon skeleton in natural products, was isolated from marine-derived Streptomyces sp. B223. Its cytotoxic activity against HCT-116 cancer cell lines with an IC(50) value of 0.34 μM was demonstrated.

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH (2021)

Article Chemistry, Organic

Asperfloketals A and B, the First Two Ergostanes with Rearranged A and D Rings: From the Sponge-Associated Aspergillus flocculosus 16D-1

Fu-Rong Jiao et al.

Summary: Asperfloketals A and B, isolated from a sponge-associated fungus, exhibit strong anti-inflammatory activity without cytotoxicity against specific cell lines.

JOURNAL OF ORGANIC CHEMISTRY (2021)

Article Chemistry, Organic

Ascandinines A-D, Indole Diterpenoids, from the Sponge-Derived Fungus Aspergillus candidus HDN15-152

Guoliang Zhou et al.

Summary: Four new indole diterpenoids, ascandinines A-D (1-4), were isolated from an Antarctic sponge-derived fungus. One of them exhibited anti-influenza virus activity, and another showed cytotoxicity against HL-60 cells.

JOURNAL OF ORGANIC CHEMISTRY (2021)

Article Chemistry, Organic

Lemnardosinanes A-I: New Bioactive Sesquiterpenoids from Soft Coral Lemnalia sp.

Mingyu Liu et al.

Summary: New rearranged nardosinane sesquiterpenoids with unique carbon skeletons were isolated from the soft coral Lemnalia sp. collected from Xisha Islands of the South China Sea. Compound 1 and 10 exhibited in vivo angiogenesis promoting activity, while compounds 3 and 4 showed antiviral activity against the H1N1 virus.

JOURNAL OF ORGANIC CHEMISTRY (2021)

Article Chemistry, Organic

A Water-Soluble 5/14-Carbobicyclic Steroid with a trans-9,11-Epoxy Ring from the Marine Dinoflagellate Amphidinium gibbosum: Insights into Late-Stage Diversification of Steroids

Li Shen et al.

Summary: Gibbosterol A, a water-soluble carbocyclic steroid discovered from the South China Sea dinoflagellate, exhibits agonistic effects against human pregnane-X-receptor. Its origin is proposed to be the late-stage oxidative cleavage of beta-sitosterol.

ORGANIC LETTERS (2021)

Article Plant Sciences

Talaromynoids A-I, Highly Oxygenated Meroterpenoids from the Marine-Derived Fungus Talaromyces purpureogenus SCSIO 41517 and Their Lipid Accumulation Inhibitory Activities

Zhong-Hui Huang et al.

Summary: Nine new highly oxygenated compounds were isolated from a marine-derived fungus, with compound 5 showing selective inhibitory activity against phosphatase CDC25B and compounds 7-9 and 12 reducing triglyceride levels in 3T3-L1 adipocytes.

JOURNAL OF NATURAL PRODUCTS (2021)

Article Chemistry, Multidisciplinary

Uncommon Bis-quinolizidine Alkaloids from the Hainan Sponge Neopetrosia chaliniformis

Bao Chen et al.

Summary: Two new bis-quinolizidine alkaloids, neopetrosiasins A and B, were isolated from the South China Sea sponge Neopetrosia chaliniformis, along with one known related analogue petrosin and three known xestospongins. The structures of the new compounds were determined through extensive spectroscopic and single-crystal X-ray analyses. Compounds 4-6 exhibited moderate cytotoxicity against several human cancer cells in bioassays.

CHINESE JOURNAL OF CHEMISTRY (2021)

Article Biochemistry & Molecular Biology

Asporychalasin, a bioactive cytochalasan with an unprecedented 6/6/11 skeleton from the Red Sea sediment Aspergillus oryzae

Raha Orfali et al.

Summary: The marine fungus Aspergillus oryzae obtained from the Red Sea sediments near Jeddah, Saudi Arabia, yielded a novel cytochalasan asporychalasin with a unique chemical structure, showing moderate antiproliferative activity against three human cancer cell lines without toxicity on zebrafish embryos.

PHYTOCHEMISTRY (2021)

Article Chemistry, Medicinal

Tedaniophorbasins A and B-Novel Fluorescent Pteridine Alkaloids Incorporating a Thiomorpholine from the Sponge Tedaniophorbas ceratosis

Asadhawut Hiranrat et al.

Summary: Two new fluorescent pteridine alkaloids, tedaniophorbasins A and B, were isolated from the sponge Tedaniophorbas ceratosis. They showed significant Stokes shifts in their fluorescence spectra but were inactive against malaria parasite strains, cancer cell lines, and protozoan parasites.

MARINE DRUGS (2021)

Article Chemistry, Organic

Dassonmycins A and B, Polycyclic Thioalkaloids from a Marine Sponge-Derived Nocardiopsis dassonvillei SCSIO 40065

Xinya Zhang et al.

Summary: Two polycyclic thioalkaloides dassonmycins A and B were isolated from Nocardiopsis dassonvillei associated with marine sponge Petrosia sp. They feature a tetracyclic ring structure and exhibit moderate antibacterial and cytotoxic activities.

ORGANIC LETTERS (2021)

Article Multidisciplinary Sciences

Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A

Kris M. White et al.

Summary: The study revealed that plitidepsin possesses potent antiviral activity against SARS-CoV-2, more effective than the approved drug remdesivir. By inhibiting the eukaryotic translation elongation factor 1A, plitidepsin can significantly reduce viral replication of SARS-CoV-2 in the lungs of mice, making it a promising candidate for COVID-19 treatment.

SCIENCE (2021)

Review Biotechnology & Applied Microbiology

Recent Advances in Silent Gene Cluster Activation in Streptomyces

Zhenyu Liu et al.

Summary: This review discusses the commonly used strategies for activating silent BGCs in Streptomyces, focusing on approaches applied in heterologous and native hosts to accelerate the discovery of natural products.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

Article Chemistry, Multidisciplinary

Production of Carminic Acid by Metabolically Engineered Escherichia coli

Dongsoo Yang et al.

Summary: Researchers have successfully biosynthesized carminic acid from glucose in engineered Escherichia coli. Through enzyme screening and optimization, the biosynthesis of carminic acid was achieved.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

Article Chemistry, Multidisciplinary

Uncommon N-Methoxyindolediketopiperazines from Acrostalagmus luteoalbus, a Marine Algal Isolate of Endophytic Fungus

Jin Cao et al.

Summary: In this study, four new compounds were isolated from a marine algal-derived fungus, showing antimicrobial and anti-acetylcholinesterase activities.

CHINESE JOURNAL OF CHEMISTRY (2021)

Article Plant Sciences

Austins-Type Meroterpenoids from a Mangrove-Derived Penicillium sp.

Meng Bai et al.

Summary: Three unusual austins-type meroterpenoids were isolated from a mangrove-derived fungus, each with unique structural features. These compounds showed inhibitory effects on the growth of Helicoverpa armigera larvae.

JOURNAL OF NATURAL PRODUCTS (2021)

Article Chemistry, Medicinal

Fusaripyridines A and B; Highly Oxygenated Antimicrobial Alkaloid Dimers Featuring an Unprecedented 1,4-Bis(2-hydroxy-1,2-dihydropyridin-2-yl)butane-2,3-dione Core from the Marine Fungus Fusarium sp. LY019

Lamiaa A. Shaala et al.

Summary: The fungal strain Fusarium sp. LY019 was isolated from the Red Sea sponge Suberea mollis, producing two novel dimeric alkaloids, fusaripyridines A and B. These compounds exhibit a unique molecular structure and antimicrobial activity, providing insights into the biosynthetic capabilities of marine-derived fungi.

MARINE DRUGS (2021)

Article Chemistry, Medicinal

Psammaceratin A: A Cytotoxic Psammaplysin Dimer Featuring an Unprecedented (2Z,3Z)-2,3-Bis(aminomethylene)succinamide Backbone from the Red Sea Sponge Pseudoceratina arabica

Diaa T. A. Youssef et al.

Summary: Bioassay-guided fractionation of extract from Red Sea sponge led to isolation of a novel dimer, psammaceratin A, and a known compound psammaplysin A, both showing significant growth inhibition activity against cancer cells.

MARINE DRUGS (2021)

Article Chemistry, Medicinal

Dermacozine N, the First Natural Linear Pentacyclic Oxazinophenazine with UV-Vis Absorption Maxima in the Near Infrared Region, along with Dermacozines O and P Isolated from the Mariana Trench Sediment Strain Dermacoccus abyssi MT 1.1T

Bertalan Juhasz et al.

Summary: Three dermacozines, dermacozines N-P, were isolated from a piezotolerant Actinomycete strain of Dermacoccus abyssi MT 1.1(T) obtained from Mariana Trench sediment in 2006. Dermacozine N (1) stands out due to its novel linear pentacyclic phenoxazine framework and potential applications in biosensing chemistry, PDT, opto-electronic applications, and metabolic mapping. Moreover, dermacozine N (1) showed weak cytotoxic activity against melanoma (A2058) and hepatocellular carcinoma cells (HepG2).

MARINE DRUGS (2021)

Article Biochemistry & Molecular Biology

Densazalin, a New Cytotoxic Diazatricyclic Alkaloid from the Marine Sponge Haliclona densaspicula

Buyng Su Hwang et al.

Summary: Densazalin, a polycyclic alkaloid isolated from a marine sponge collected in Korea, possesses a unique structure and exhibits cytotoxic activity against two human tumor cell lines.

MOLECULES (2021)

Article Chemistry, Organic

Sinunanolobatone A, an Anti-inflammatory Diterpenoid with Bicyclo[13.1.0]pentadecane Carbon Scaffold, and Related Casbanes from the Sanya Soft Coral Sinularia nanolobata

Zi-Rong Zeng et al.

Summary: A novel diterpenoid, sinunanolobatone A (1), with an unprecedented carbon framework, along with new casbane diterpenoids (2 and 3) and known related compounds (4-8) were isolated from the Sanya soft coral Sinularia nanolobata. The structure of the new compounds was determined using various analytical methods and a biosynthetic pathway for compound 1 was proposed. Compound 1 exhibited significant inhibitory activity against LPS-induced inflammation in BV-2 microglial cells.

ORGANIC LETTERS (2021)

Article Chemistry, Organic

Sinusiaetone A, an Anti-inflammatory Norditerpenoid with a Bicyclo[11.3.0]hexadecane Nucleus from the Hainan Soft Coral Sinularia siaesensis

Zi-Hui Chen et al.

Summary: A novel norditerpenoid and four polyoxygenated cembranoids were isolated from the Hainan soft coral Sinularia siaesensis, with their structures elucidated through various methodologies. The study also proposed a biosynthetic pathway for the novel compound and demonstrated their inhibitory activity against inflammation in BV-2 microglial cells.

ORGANIC LETTERS (2021)

Article Biochemistry & Molecular Biology

Pyrazinopyrimidine alkaloids from a mangrove-derived fungus Aspergillus versicolor HDN11-84

Feng Li et al.

Summary: This study identified four new pyrazinopyrimidine-type alkaloids, including three natural products and one artifact, from a mangrove-derived fungus extract. These compounds exhibit unique structures and possess potential anti-influenza virus activity.

PHYTOCHEMISTRY (2021)

Article Chemistry, Multidisciplinary

Discovery of benthol A and its challenging stereochemical assignment: opening up a new window for skeletal diversity of super-carbon-chain compounds

Zhong-Ping Jiang et al.

Summary: Super-carbon-chain compounds (SCCCs) are marine organic molecules with long polyol carbon chains and numerous stereocenters. Benthol A, an aberrant SCCC obtained from a South China Sea benthic dinoflagellate, displays potent antimalarial activity and unique structural features, placing it in a new SCCC family termed polyol-polyether compounds. This discovery not only sheds light on untapped biosynthetic potential of marine dinoflagellates, but also adds to the skeletal diversity of SCCCs.

CHEMICAL SCIENCE (2021)

Article Chemistry, Organic

Discovery of a new asymmetric dimer nenestatin B and implications of a dimerizing enzyme in a deep sea actinomycete

Xiaodong Jiang et al.

Summary: Benzofluorene-containing atypical angucyclines are an important family of natural products with a wide range of antibacterial and cytotoxic properties. Interestingly, symmetric and asymmetric dimers have shown better activity than monomers in this class of compounds. The structural elucidation of nenestatin C (3) highlights the essential role of Nes18 in the biosynthetic pathway of nenestatin B (2), specifically in dimerization via C-C bond formation.

ORGANIC & BIOMOLECULAR CHEMISTRY (2021)

Article Chemistry, Applied

Neo-debromoaplysiatoxin C, with new structural rearrangement, derived from debromoaplysiatoxin

Yang-Hua Tang et al.

NATURAL PRODUCT RESEARCH (2020)

Article Chemistry, Organic

Discovery of an Isothiazolinone-Containing Antitubercular Natural Product Levesquamide

Libang Liang et al.

JOURNAL OF ORGANIC CHEMISTRY (2020)

Article Plant Sciences

Bioactive Alkaloids from the Actinomycete Actinoalloteichus sp. ZZ1866

Le Qin et al.

JOURNAL OF NATURAL PRODUCTS (2020)

Article Chemistry, Organic

Structural elucidation, total synthesis, and cytotoxic activity of effphenol A

Hongxin Liu et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2020)

Article Biochemistry & Molecular Biology

Uncommon terpenoids with anti-inflammatory activity from the Hainan soft coral Sinularia tumulosa

You-Sheng Cai et al.

BIOORGANIC CHEMISTRY (2020)

Article Biochemistry & Molecular Biology

Harzianoic acids A and B, new natural scaffolds with inhibitory effects against hepatitis C virus

Bo Li et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2019)

Article Chemistry, Multidisciplinary

Computationally Assisted Discovery and Assignment of a Highly Strained and PANC-1 Selective Alkaloid from Alaska's Deep Ocean

Yike Zou et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

Article Chemistry, Organic

Vagiallene, a Rearranged C15 Acetogenin from Laurencia obtusa

Stamatios Perdikaris et al.

ORGANIC LETTERS (2019)

Article Chemistry, Multidisciplinary

Chartrenoline, a novel alkaloid isolated from a marine Streptomyces chartreusis NA02069

Chengli Liu et al.

CHINESE CHEMICAL LETTERS (2019)

Article Chemistry, Organic

Nitrogenous cyclonerane sesquiterpenes from an algicolous strain of Trichoderma asperellum

Yin-Ping Song et al.

ORGANIC CHEMISTRY FRONTIERS (2019)

Article Chemistry, Organic

Sorbicillfurans A and B, two novel sorbicillinoid adducts from the fungus Penicillium citrinum SCSIO41402

Jianjiao Wang et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2019)

Article Chemistry, Organic

KB343, a Cyclic Tris-guanidine Alkaloid from Palauan Zoantharian Epizoanthus illoricatus

Ken Matsumura et al.

ORGANIC LETTERS (2018)

Article Plant Sciences

Lamellodysidines A and B, Sesquiterpenes Isolated from the Marine Sponge Lamellodysidea herbacea

Masumi Torii et al.

JOURNAL OF NATURAL PRODUCTS (2017)

Article Chemistry, Organic

Iodinated Meroditerpenes from a Red Alga Callophycus sp

Serge Lavoie et al.

JOURNAL OF ORGANIC CHEMISTRY (2017)

Article Biochemistry & Molecular Biology

Metagenomic discovery of polybrominated diphenyl ether biosynthesis by marine sponges

Vinayak Agarwal et al.

NATURE CHEMICAL BIOLOGY (2017)

Article Chemistry, Organic

Cytotoxic indole alkaloids from Pseudovibrio denitrificans BBCC725

Alice M. S. Rodrigues et al.

TETRAHEDRON LETTERS (2017)

Article Chemistry, Organic

Aspochalazine A, a novel polycyclic aspochalasin from the fungus Aspergillus sp Z4

Xinyang Li et al.

TETRAHEDRON LETTERS (2017)

Article Chemistry, Multidisciplinary

Hydroquinone derivatives from the marine-derived fungus Gliomastix sp.

Mohamed S. Elnaggar et al.

RSC ADVANCES (2017)

Article Chemistry, Multidisciplinary

Taichunamides: Prenylated Indole Alkaloids from Aspergillus taichungensis (IBT 19404)

Ippei Kagiyama et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)

Article Chemistry, Organic

Lissodendrins A and B: 2-Aminoimidazole Alkaloids from the Marine Sponge Lissodendoryx (Acanthodoryx) fibrosa

Amin Mokhlesi et al.

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2016)

Article Chemistry, Medicinal

Citrinovirin with a new norditerpene skeleton from the marine algicolous fungus Trichoderma citrinoviride

Xiao-Rui Liang et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2016)

Article Plant Sciences

Callyazepin and (3R)-Methylazacyclodecane, Nitrogenous Macrocycles from a Callyspongia sp Sponge

Chang-Kwon Kim et al.

JOURNAL OF NATURAL PRODUCTS (2016)

Article Plant Sciences

Unique Polybrominated Hydrocarbons from the Australian Endemic Red Alga Ptilonia australasica

Trong D. Tran et al.

JOURNAL OF NATURAL PRODUCTS (2016)

Article Chemistry, Organic

Characterization and Synthesis of Eudistidine C, a Bioactive Marine Alkaloid with an Intriguing Molecular Scaffold

Susanna T. S. Chan et al.

JOURNAL OF ORGANIC CHEMISTRY (2016)

Article Chemistry, Organic

Sesterterpenoids Isolated from the Sponge Phorbas sp Activate Latent HIV-1 Provirus Expression

Meng Wang et al.

JOURNAL OF ORGANIC CHEMISTRY (2016)

Article Chemistry, Organic

Lanesoic Acid: A Cytotoxic Zwitterion from Theonella sp.

Jaime Rodriguez et al.

ORGANIC LETTERS (2016)

Article Chemistry, Multidisciplinary

Aplysiasecosterol A: A 9,11-Secosteroid with an Unprecedented Tricyclic γ-Diketone Structure from the Sea Hare Aplysia kurodai

Atsushi Kawamura et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)

Article Chemistry, Medicinal

Sandensone A, a novel sesquiterpenoid from the Formosan soft coral Sinularia sandensis

Shi-Yie Cheng et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2015)

Article Chemistry, Organic

Oximoaspergillimide, a Fungal Derivative from a Marine Isolate of Aspergillus sp.

Faviola Cardoso-Martinez et al.

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2015)

Article Chemistry, Organic

Diterpenes with Unprecedented Skeletons from the Red Alga Sphaerococcus coronopifolius

Vangelis Smyrniotopoulos et al.

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2015)

Article Chemistry, Organic

Salinipostins A-K, Long-Chain Bicyclic Phosphotriesters as a Potent and Selective Antimalarial Chemotype

Christopher J. Schulze et al.

JOURNAL OF ORGANIC CHEMISTRY (2015)

Article Chemistry, Multidisciplinary

Structure and Absolute Configuration of Jurassic Polyketide-Derived Spiroborate Pigments Obtained from Microgram Quantities

Klaus Wolkenstein et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2015)

Article Chemistry, Organic

Jahanyne, an Apoptosis-Inducing Lipopeptide from the Marine Cyanobacterium Lyngbya sp.

Arihiro Iwasaki et al.

ORGANIC LETTERS (2015)

Article Chemistry, Organic

Asterolloside, a novel enolic saccharide from the sea star Asterias rollestoni Bell

Xian-Wen Yang et al.

TETRAHEDRON LETTERS (2015)

Article Chemistry, Multidisciplinary

Spiroplakortone, an unprecedented spiroketal lactone from the Chinese sponge Plakortis simplex

Giuseppina Chianese et al.

RSC ADVANCES (2015)

Article Plant Sciences

Monanchosterols A and B, Bioactive Bicyclo[4.3.1]steroids from a Korean Sponge Monanchora sp.

Weihong Wang et al.

JOURNAL OF NATURAL PRODUCTS (2015)

Article Chemistry, Multidisciplinary

Forazoline A: Marine-Derived Polyketide with Antifungal In Vivo Efficacy

Thomas P. Wyche et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)

Article Plant Sciences

Penicillipyrones A and B, Meroterpenoids from a Marine-Derived Penicillium sp Fungus

Lijuan Liao et al.

JOURNAL OF NATURAL PRODUCTS (2014)

Article Plant Sciences

Mahorones, Highly Brominated Cyclopentenones from the Red Alga Asparagopsis taxiformis

Stephane Greff et al.

JOURNAL OF NATURAL PRODUCTS (2014)

Article Plant Sciences

Dysideanones A-C, Unusual Sesquiterpene Quinones from the South China Sea Sponge Dysidea avara

Wei-Hua Jiao et al.

JOURNAL OF NATURAL PRODUCTS (2014)

Article Chemistry, Organic

Callyspongiolide, a Cytotoxic Macrolide from the Marine Sponge Callyspongia sp.

Cong-Dat Pham et al.

ORGANIC LETTERS (2014)

Article Chemistry, Organic

Belizentrin, a Highly Bioactive Macrocycle from the Dinoflagellate Prorocentrum belizeanum

Humberto J. Dominguez et al.

ORGANIC LETTERS (2014)

Article Chemistry, Organic

Shagenes A and B, New Tricyclic Sesquiterpenes Produced by an Undescribed Antarctic Octocoral

Jacqueline L. von Salm et al.

ORGANIC LETTERS (2014)

Article Chemistry, Organic

Kuroshines A and B, new alkaloids from Zoanthus kuroshio

Yuan-Bin Cheng et al.

TETRAHEDRON LETTERS (2014)

Article Chemistry, Organic

Alkaloids and citrinins from marine-derived fungus Nigrospora oryzae SCSGAF 0111

Jie-Jie Dong et al.

TETRAHEDRON LETTERS (2014)

Article Chemistry, Organic

Capillosananes S-Z, new sesquiterpenoids from the soft coral Sinularia capillosa

Dawei Chen et al.

TETRAHEDRON LETTERS (2014)

Article Chemistry, Medicinal

Caulerprenylols A and B, two rare antifungal prenylated para-xylenes from the green alga Caulerpa racemosa

Ai-Hong Liu et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2013)

Article Chemistry, Multidisciplinary

Salimabromide: Unexpected Chemistry from the Obligate Marine Myxobacterium Enhygromxyasalina

Stephan Felder et al.

CHEMISTRY-A EUROPEAN JOURNAL (2013)

Article Chemistry, Organic

Alkaloids from the Sponge-Associated Fungus Aspergillus sp.

Yaming Zhou et al.

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2013)

Article Plant Sciences

Fasciospyrinadine, a novel sesquiterpene pyridine alkaloid from a Guangxi sponge Fasciospongia sp.

Zheng-Bao Zhao et al.

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH (2013)

Article Plant Sciences

Unprecedented Polyketides from a Marine Sponge-Associated Stachylidium sp.

Celso Almeida et al.

JOURNAL OF NATURAL PRODUCTS (2013)

Article Chemistry, Organic

Thiaplakortones A-D: Antimalarial Thiazine Alkaloids from the Australian Marine Sponge Plakortis lita

Rohan A. Davis et al.

JOURNAL OF ORGANIC CHEMISTRY (2013)

Article Chemistry, Multidisciplinary

Discoipyrroles A-D: Isolation, Structure Determination, and Synthesis of Potent Migration Inhibitors from Bacillus hunanensis

Youcai Hu et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)

Article Chemistry, Multidisciplinary

Isolation and First Total Synthesis of PM050489 and PM060184, Two New Marine Anticancer Compounds

Maria Jesus Martin et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)

Article Chemistry, Organic

New Polyaromatic Metabolites from a Marine-Derived Fungus Penicillium sp.

Elin Julianti et al.

ORGANIC LETTERS (2013)

Article Chemistry, Organic

Aspeverin, a New Alkaloid from an Algicolous Strain of Aspergillus versicolor

Nai-Yun Ji et al.

ORGANIC LETTERS (2013)

Article Chemistry, Organic

Manzamenone O, New Trimeric Fatty Acid Derivative from a Marine Sponge Plakortis sp.

Naonobu Tanaka et al.

ORGANIC LETTERS (2013)

Article Chemistry, Organic

Sinulanorcembranolide A, a novel norcembranoidal diterpene from the octocoral Sinularia gaweli

Wei-Hsuan Yen et al.

TETRAHEDRON LETTERS (2013)

Article Chemistry, Organic

Perezoperezone and curcuperezone: bisabolane dimers from the soft coral Pseudopterogorgia rigida

Panagiota Georgantea et al.

TETRAHEDRON LETTERS (2013)

Review Biochemistry & Molecular Biology

Lessons from the Past and Charting the Future of Marine Natural Products Drug Discovery and Chemical Biology

William H. Gerwick et al.

CHEMISTRY & BIOLOGY (2012)

Article Chemistry, Medicinal

Bromophenol coupled with diketopiperazine from marine red alga Symphyocladia latiuscula

Xiuli Xu et al.

CHEMISTRY OF NATURAL COMPOUNDS (2012)

Article Chemistry, Organic

Diterpenoids from Marine Ciliates: Chemical Polymorphism of Euplotes rariseta

Graziano Guella et al.

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2012)

Article Chemistry, Organic

Polyketide Skeletons from the Marine Alga-Derived Fungus Coniothyrium cereale

Mahmoud Fahmi Elsebai et al.

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2012)

Article Plant Sciences

Dactylomelatriol, a Biogenetically Intriguing Omphalane-Derived Marine Sesquiterpene

Ana-R. Diaz-Marrero et al.

JOURNAL OF NATURAL PRODUCTS (2012)

Article Chemistry, Organic

Bromophycoic Adds: Bioactive Natural Products from a Fijian Red Alga Callophycus sp.

Margaret E. Teasdale et al.

JOURNAL OF ORGANIC CHEMISTRY (2012)

Article Chemistry, Multidisciplinary

Merochlorins A-D, Cyclic Meroterpenoid Antibiotics Biosynthesized in Divergent Pathways with Vanadium-Dependent Chloroperoxidases

Leonard Kaysser et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)

Review Biochemistry & Molecular Biology

The impact of the United Nations Convention on Biological Diversity on natural products research

Gordon M. Cragg et al.

NATURAL PRODUCT REPORTS (2012)

Article Chemistry, Applied

Bioactive metabolites from a marine-derived strain of the fungus Neosartorya fischeri

Qing-Wei Tan et al.

NATURAL PRODUCT RESEARCH (2012)

Article Plant Sciences

A new bicyclic sesquiterpene from the marine sponge associated fungus Emericellopsis minima

Angela Pinheiro et al.

PHYTOCHEMISTRY LETTERS (2012)

Article Chemistry, Organic

Dysidavarones A-D, New Sesquiterpene Quinones from the Marine Sponge Dysidea avara

Wei-Hua Jiao et al.

ORGANIC LETTERS (2012)

Article Chemistry, Organic

Ieodoglucomides A and B from a Marine-Derived Bacterium Bacillus licheniformis

Fakir Shahidullah Tareq et al.

ORGANIC LETTERS (2012)

Article Chemistry, Organic

Spiroindimicins A-D: New Bisindole Alkaloids from a Deep-Sea-Derived Actinomycete

Wenjun Zhang et al.

ORGANIC LETTERS (2012)

Article Chemistry, Organic

Pavidolides A-E, new cembranoids from the soft coral Sinularia pavida

Shi Shen et al.

TETRAHEDRON LETTERS (2012)

Article Chemistry, Organic

Acremolin, a new 1H-azirine metabolite from the marine-derived fungus Acremonium strictum

Elin Julianti et al.

TETRAHEDRON LETTERS (2012)

Article Chemistry, Multidisciplinary

Halichonines A, B, and C, novel sesquiterpene alkaloids from the marine sponge Halichondria okadai Kadota

Osamu Ohno et al.

CHEMICAL COMMUNICATIONS (2011)

Article Plant Sciences

Acremostrictin, a Highly Oxygenated Metabolite from the Marine Fungus Acremonium strictum

Elin Julianti et al.

JOURNAL OF NATURAL PRODUCTS (2011)

Article Chemistry, Organic

Mollenyne A, a Long-Chain Chlorodibromohydrin Amide from the Sponge Spirastrella mollis

Brandon I. Morinaka et al.

ORGANIC LETTERS (2011)

Article Chemistry, Organic

Erythrazoles A-B, Cytotoxic Benzothiazoles from a Marine-Derived Erythrobacter sp.

Youcai Hu et al.

ORGANIC LETTERS (2011)

Review Biotechnology & Applied Microbiology

Drug development from marine natural products

Tadeusz F. Molinski et al.

NATURE REVIEWS DRUG DISCOVERY (2009)

Review Oncology

Marine organisms as a source of new anticancer agents

Gilberto Schwartsmann et al.

LANCET ONCOLOGY (2001)