期刊
CHINESE JOURNAL OF CHEMISTRY
卷 40, 期 15, 页码 1867-1889出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cjoc.202200129
关键词
Natural products; Marine drugs; Biological activity; Drug discovery; Novel structures
资金
- National Natural Science Foundation of China [U2006204, 41776136, 2181101213, 32000039]
This review presents a comprehensive summary of 243 hot-spot marine natural products reported from 2012 to 2021, providing important chemical and biological inspirations for marine natural product study and marine drug development. It also introduces some general rules regarding these outstanding compounds.
Comprehensive Summary The vast marine ecosystem contains a sea of natural products, which are potential model molecules for new drug development. With more than one thousand new structures been discovered each year, the past decade has become the golden time for marine natural product discovery, leading to a valuable but extra-large chemical database. Serving as an epitome of the most promising compounds, which take the ultra-new skeletons and/or excellent bioactivities, this review covers 243 hot-spot marine natural products reported from 2012 to 2021, to abstract some important chemical and/or biological inspirations for marine natural product study and marine drug development in the future. In addition, some general rules regarding to the source organism, structure-specialty, organism-structure specificity, and organism-bioactivity relationship of these outstanding compounds will also be presented.
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