期刊
CHEMOSPHERE
卷 294, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.chemosphere.2022.133810
关键词
Microplastics; Antibiotic; Bioaccumulation; Antibiotic resistance genes; Synergistic effect
资金
- Youth Innovation Promotion Association CAS [2021212]
- Natural Science Foundation of Shandong Province [ZR2021MD039]
- National Natural Science Foundation of China [41807032, 41601525]
- Plan Project of Shandong Science and Technology Development [2013YD21010]
- Taishan Scholar Project Special Funding [ts20190962]
Microplastics reduce the bioaccumulation of sulfamethoxazole in mice tissues, while exacerbating its effects on gut microbiota and antibiotic resistance gene profiles, indicating high risks to humans.
Microplastics (MPs) have aroused a global health concern and their coexistence with antibiotics is inevitable. However, how MPs would affect the bioaccumulation and risks of antibiotics in humans remains poorly understood. Here a mouse model was used, and through dietary exposure, we observed that while the relative distributions of sulfamethoxazole (SMX) in tissues were relatively stable, MPs significantly reduced the bioaccumulation of SMX in mice tissues (liver, lung, spleen, heart and kidney). Notably, while SMX and MPs showed a differential effect, MPs could exacerbate the effects of SMX on gut microbiota and antibiotic resistance gene (ARG) profile, with the relative abundances of sulfonamide resistance genes and multidrug genes being significantly increased. We further identified that shifts in gut microbiota contributed to the changes in ARG profiles in mice. Combined, our results demonstrate that MPs reduced the bioaccumulation of SMX, but they enhanced its effects on gut microbiota and the antibiotic resistome of mice, indicating they might have high risks to humans.
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