4.7 Article

Particulate matter (PM10) destabilizes mitotic spindle through downregulation of SETD2 in A549 lung cancer cells

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Summary: PM10 exposure increases chromosomal instability in lung cancer cells by affecting the expression levels of long non-coding RNA NORAD and components of the spindle assembly checkpoint (SAC). Aneuploidy events are induced by SAC deregulation due to PM10 treatment.

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