4.5 Article

Synthesis, in vitro Antileishmanial Efficacy and Hit/Lead Identification of Nitrofurantoin-Triazole Hybrids

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Chemistry, Physical

An overview on applications of SwissADME web tool in the design and development of anticancer, antitubercular and antimicrobial agents: A medicinal chemist's perspective

Bulti Bakchi et al.

Summary: In silico techniques, particularly the SwissADME tool, have gained popularity in small molecule drug discovery. This tool allows for hit generation, interaction pattern determination, and prediction of physicochemical and pharmacokinetic parameters. This article discusses the role of SwissADME in the design and development of anticancer, antitubercular, and antimicrobial agents.

JOURNAL OF MOLECULAR STRUCTURE (2022)

Article Immunology

Mutations in an Aquaglyceroporin as a Proven Marker of Antimony Clinical Resistance in the Parasite Leishmania donovani

Jade-Eva Potvin et al.

Summary: This study identified gene mutations in AQP1 associated with antimony resistance in Leishmania donovani by sequencing the genomes of clinical isolates and conducting experimental validation through CRISPR-Cas9-mediated genome editing. Restoring the wild-type AQP1 in resistant isolates sensitized them to antimonials, while introducing the mutation in sensitive isolates led to antimony resistance. Through genomic analysis and gene editing, the role of AQP1 mutations in clinical resistance was confirmed.

CLINICAL INFECTIOUS DISEASES (2021)

Article Chemistry, Medicinal

Synthesis and in vitro antileishmanial efficacy of novel benzothiadiazine-1,1-dioxide derivatives

Daisy K. Mangwegape et al.

Summary: Leishmaniasis is a major parasitic disease affecting tropical and subtropical developing countries, with limited treatment options. Through in vitro experiments with benzothiadiazine derivatives, it was found that these compounds have potential as antileishmanial agents by showing activity against parasites and no toxicity to mammalian cells.

ARCHIV DER PHARMAZIE (2021)

Article Integrative & Complementary Medicine

Bio-guided isolation of anti-leishmanial natural products from Diospyros gracilescens L. (Ebenaceae)

Cyrille Armel N. Njanpa et al.

Summary: The study aimed to discover new inhibitors of Leishmania spp. using extracts from Diospyros gracilescens. The hydroethanolic crude extract of D. gracilescens trunk showed the most potent antileishmanial activity, with the hexane fraction showing the most potent activity. Further studies on the isolated compounds could lead to potential drug discovery for visceral leishmaniasis.

BMC COMPLEMENTARY MEDICINE AND THERAPIES (2021)

Article Biochemistry & Molecular Biology

Synthesis, activity, and molecular modeling studies of 1,2,3-triazole derivatives from natural phenylpropanoids as new trypanocidal agents

Thiago Belarmino de Souza et al.

CHEMICAL BIOLOGY & DRUG DESIGN (2020)

Article Pharmacology & Pharmacy

Formulation strategy of nitrofurantoin: co-crystal or solid dispersion?

Xin-Yi Teoh et al.

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY (2020)

Article Chemistry, Organic

Synthesis, antibacterial, and antioxidant activities of naphthyl-linked disubstituted 1,2,3-triazoles

Chander Prakash Kaushik et al.

JOURNAL OF HETEROCYCLIC CHEMISTRY (2020)

Article Chemistry, Medicinal

Synthesis and in vitro antimycobacterial and antileishmanial activities of hydroquinone-triazole hybrids

Chris-Marie Horn et al.

MEDICINAL CHEMISTRY RESEARCH (2020)

Review Biotechnology & Applied Microbiology

Recent advances and new strategies on leishmaniasis treatment

Bruno Mendes Roatt et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2020)

Article Pharmacology & Pharmacy

Discovery of Icotinib-1,2,3-Triazole Derivatives as IDO1 Inhibitors

Long-fei Mao et al.

FRONTIERS IN PHARMACOLOGY (2020)

Review Biochemistry & Molecular Biology

Overcoming cancer therapeutic bottleneck by drug repurposing

Zhe Zhang et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Article Biochemistry & Molecular Biology

Design, synthesis, and antimycobacterial activity of novel ciprofloxacin derivatives

Pieter Cilliers et al.

CHEMICAL BIOLOGY & DRUG DESIGN (2019)

Review Chemistry, Medicinal

Molecular Hybridization as a Tool for Designing Multitarget Drug Candidates for Complex Diseases

Viktoriya Ivasiv et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2019)

Article Biotechnology & Applied Microbiology

Computational Assessment of the Pharmacological Profiles of Degradation Products of Chitosan

Diana Larisa Roman et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2019)

Article Chemistry, Multidisciplinary

Potential Antileishmanial Activity of a Triazole-Based Hybrid Peptide against Leishmania major

Krishnendu Maji et al.

CHEMISTRYSELECT (2018)

Article Pharmacology & Pharmacy

Azoreductases in drug metabolism

Ali Ryan

BRITISH JOURNAL OF PHARMACOLOGY (2017)

Review Chemistry, Medicinal

Triazole derivatives and their anti-tubercular activity

Shu Zhang et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)

Review Chemistry, Medicinal

Marine-Derived Penicillium Species as Producers of Cytotoxic Metabolites

Sen Liu et al.

MARINE DRUGS (2017)

Letter Biochemistry & Molecular Biology

The Drug Repurposing Hub: a next-generation drug library and information resource

Steven M. Corsello et al.

NATURE MEDICINE (2017)

Article Biochemistry & Molecular Biology

Antitrypanosomal and antileishmanial activity of prenyl-1,2,3-triazoles

Exequiel O. J. Porta et al.

MEDCHEMCOMM (2017)

Article Parasitology

Effects of nitro-heterocyclic derivatives against Leishmania (Leishmania) infantum promastigotes and intracellular amastigotes

Simone Carolina Soares Petri e Silva et al.

EXPERIMENTAL PARASITOLOGY (2016)

Article Biotechnology & Applied Microbiology

Hit and lead criteria in drug discovery for infectious diseases of the developing world

Kei Katsuno et al.

NATURE REVIEWS DRUG DISCOVERY (2015)

Article Biochemistry & Molecular Biology

ALDH2 Mediates 5-Nitrofuran Activity in Multiple Species

Linna Zhou et al.

CHEMISTRY & BIOLOGY (2012)

Review Pharmacology & Pharmacy

Mechanisms of Drug Toxicity and Relevance to Pharmaceutical Development

F. Peter Guengerich

DRUG METABOLISM AND PHARMACOKINETICS (2011)

Article Pharmacology & Pharmacy

The Distribution of Nifurtimox Across the Healthy and Trypanosome-Infected Murine Blood-Brain and Blood-Cerebrospinal Fluid Barriers

Sinthujah Jeganathan et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2011)

Review Pharmacology & Pharmacy

Lipophilicity in drug discovery

Michael J. Waring

EXPERT OPINION ON DRUG DISCOVERY (2010)

Article Infectious Diseases

Antileishmanial High-Throughput Drug Screening Reveals Drug Candidates with New Scaffolds

Jair L. Siqueira-Neto et al.

PLOS NEGLECTED TROPICAL DISEASES (2010)

Review Parasitology

Evolution of the Apicomplexa: where are we now?

David A. Morrison

TRENDS IN PARASITOLOGY (2009)

Article Pharmacology & Pharmacy

A retrospective review assessing the efficacy and safety of nitrofurantoin in renal impairment

Ajay Bains et al.

CANADIAN PHARMACISTS JOURNAL (2009)

Article Biochemistry & Molecular Biology

Role of cytochrome P450 reductase in nitrofurantoin-induced redox cycling and cytotoxicity

Yuri Wang et al.

FREE RADICAL BIOLOGY AND MEDICINE (2008)

Review Microbiology

Reduction of polynitroaromatic compounds: the bacterial nitroreductases

Maria Dolores Roldan et al.

FEMS MICROBIOLOGY REVIEWS (2008)

Article Chemistry, Multidisciplinary

ESOL: Estimating aqueous solubility directly from molecular structure

JS Delaney

JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES (2004)

Article Chemistry, Medicinal

Molecular properties that influence the oral bioavailability of drug candidates

DF Veber et al.

JOURNAL OF MEDICINAL CHEMISTRY (2002)

Review Pharmacology & Pharmacy

A mechanistic approach to understanding the factors affecting drug absorption: A review of fundamentals

MN Martinez et al.

JOURNAL OF CLINICAL PHARMACOLOGY (2002)