4.6 Article

anti-Markovnikov Iodofluorination of Alkenes

期刊

CHEMISTRY-AN ASIAN JOURNAL
卷 17, 期 9, 页码 -

出版社

WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.202200184

关键词

anti-Markovnikov Addition; Iodofluorination; Alkenes; Fluorine; Tertiary C-F bonds

资金

  1. National Key Research and Development Program of China [2021YFF0701700]
  2. National Natural Science Foundation [21971252, 21991122, 21672138]
  3. Key Research Program of Frontier Sciences, Chinese Academy of Sciences (CAS) [QYZDJSSWSLH049]
  4. Science and Technology Commission of Shanghai Municipality [22ZR1423600]

向作者/读者索取更多资源

In this paper, a convenient anti-Markovnikov iodofluorination of alkenes was described using Selectfluor/(Bu4NI)-Bu-n as the reagent. The reaction showed a broad substrate scope, good functional group tolerance, and the ability to construct various C-F bonds.
The fluorination of alkenes with electrophilic N-F type reagents usually occurs through a Markovnikov-type addition, and the anti-Markovnikov-type addition may require the use of a transition metal catalyst or an expensive catalyst. Herein we describe a convenient anti-Markovnikov iodofluorination of alkenes with Selectfluor/(Bu4NI)-Bu-n. A wide substrate scope and good functional group tolerance were observed. The process allows for the construction of various C-F bonds, especially tertiary C-F bonds. The remarkable features make this protocol attractive, including convenient operations, simple reaction conditions, and the installation of an iodine atom which provides possibilities for further transformations.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据