Rising Interest in the Development of Metal Complexes in Cancer Immunotherapy

Metal complexes have shown great potential in cancer immunotherapy. This review briefly introduces the basic concepts and strategies of cancer immunotherapy and summarizes the recent discoveries on the immune effects of traditional platinum-based anticancer compounds. In addition, we also outline the latest research progresses on metal complexes for cancer immunotherapy focusing on platinum, ruthenium, iridium, rhenium and copper complexes. Finally, the research perspectives and unsolved problems on the applications of metallo-anticancer agents in cancer immunotherapy are purposed.

Automated summary

This review introduces the potential of metal complexes in cancer immunotherapy and summarizes recent discoveries on the immune effects of platinum-based compounds. It also outlines the latest research on metal complexes for cancer immunotherapy, focusing on platinum, ruthenium, iridium, rhenium, and copper complexes. Finally, it discusses research perspectives and unresolved problems in the application of metallo-anticancer agents in cancer immunotherapy.