期刊
CHEMISTRY-AN ASIAN JOURNAL
卷 17, 期 13, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.202200310
关键词
branched DNA; DNA nanostructure; diagnosis; therapeutics; protein engineering
资金
- National Natural Science Foundation of China [21621004, 22174097]
This review focuses on the construction of branched DNA-based nanostructures for biological and biomedical applications. It discusses the molecular design, synthesis methods, and construction strategies. The review provides guidance for the further development of branched DNA-based nanomaterials in the field of biomedicine.
Branched DNA with multibranch-like anisotropic topology serves as a promising and powerful building block in constructing multifunctional-integrated nanomaterials in a programmable and controllable manner. Recently, a series of branched DNA-based functional nanomaterials were developed by elaborate molecular design. In this review, we focused on the construction of branched DNA-based nanostructures for biological and biomedical applications. First, the molecular design and synthesis method of branched DNA monomer were briefly described. Then, the construction strategies of branched DNA-based nanostructures were categorially discussed, including target-triggered polymerization, enzymatic extension and hybrid assembly. Finally, the biological and biomedical applications including diagnosis, therapeutics and protein engineering were summarized. We envision that the review will contribute to the further development of branched DNA-based nanomaterials with great application potential in the field of biomedicine, thus building a new bridge between material chemistry and biomedicine.
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