期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 28, 期 44, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202201356
关键词
amides; carbon monoxide; carbonylation; copper catalysis; cross-coupling
资金
- Oril Industrie, affiliated to Les Laboratoires Servier
- Universite libre de Bruxelles (ULB)
- FNRS [PDR T.0160.18]
In this study, a general copper-catalyzed carbonylative cross-coupling between amines and alkyl iodides was reported. The reaction showed good efficiency and broad substrate scope, making it potentially valuable for industrial applications.
A general copper-catalyzed carbonylative cross-coupling between amines and alkyl iodides is reported. Using a simple combination of catalytic amounts of copper(I) chloride and N,N,N',N,N-pentamethyldiethylenetriamine in the presence of sodium hydroxide under carbon monoxide pressure, a broad range of alkyl iodides and amines can be efficiently coupled to the corresponding amides that are obtained in good to excellent yields. Notable features of this process - the first one relying on a base metal catalyst - include the availability and low cost of the catalytic system, its successful use with primary, secondary, tertiary alkyl iodides and all classes of amines - with no or limited competing nucleophilic substitution without CO incorporation - as well as its efficiency with complex alkyl iodides and amines. Mechanistic studies demonstrated that a radical pathway is operative and the key role of CO.
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