期刊
CHEMISTRY OF MATERIALS
卷 34, 期 9, 页码 4001-4018出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.chemmater.2c00079
关键词
-
资金
- Polish National Agency for Academic Exchange [PPI/APM/2018/1/00049/U/001]
- National Science Foundation SBIR [1843616]
- Div Of Industrial Innovation & Partnersh
- Directorate For Engineering [1843616] Funding Source: National Science Foundation
In this study, copper-zinc ferrite nanoparticles coated with a poly(ethylene glycol) layer were synthesized and embedded into agarose gel, successfully designing a novel temperature-sensitive contrast agent for magnetic resonance imaging (MRI). The experimental results showed a strong correlation between temperature and image intensity in MR images of the contrast agent under a temperature gradient.
Superparamagnetic ferrite nanoparticles coated witha polymer layer are widely used for biomedical applications. Theobjective of this work is to design nanoparticles as a magneticresonance imaging (MRI) temperature-sensitive contrast agent.Copper-zinc ferrite nanoparticles coated with a poly(ethyleneglycol) (PEG) layer are synthesized using a one-step thermaldecompositionmethodinapolymermatrix.Theresultingnanoparticles are stable in water and biocompatible. UsingMo??ssbauer spectroscopy and magnetometry, it was determinedthat the grown nanoparticles exhibit superparamagnetic properties.Embedding these particles into an agarose gel resulted in significantmodification of water proton relaxation timesT1,T2, andT2*determined by nuclear magnetic resonance measurements. Theresults of the spin-echoT2-weighted MR images of an aqueous phantom with embedded Cu0.08Zn0.54Fe2.38O4nanoparticles in thepresence of a strong temperature gradient show a strong correlation between the temperature and the image intensity. The presentedresults support the hypothesis that CuZn ferrite nanoparticles can be used as a contrast agent for MRI thermometry.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据