4.5 Review

Exploration of Potent Cytotoxic Molecules from Fungi in Recent Past to Discover Plausible Anticancer Scaffolds

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Summary: Fungi are a rich source of novel anticancer compounds, with four polyketide-amino acid hybrid compounds isolated from the fungus Thermothelomyces thermophilus exhibiting promising cytotoxicity against some cell lines derived from colorectal carcinoma, hepatic carcinoma and gastric carcinoma. The structure of the new compound myceliothermophin F was clearly determined using a combination of NMR analysis and HRESIMS, indicating that compounds with trans-fused decalin system could be promising in developing novel anticancer drugs.

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