MiR-203a-3p/153-3p improves cognitive impairments induced by ischemia/reperfusion via blockade of SRC-mediated MAPK signaling pathway in ischemic stroke

Article Cell Biology

Inhibition of microRNA-29b suppresses oxidative stress and reduces apoptosis in ischemic stroke

Yao-Hua Ma et al.

Summary: MiR-29b plays a critical role in brain homeostasis and inhibiting its expression can reduce cell apoptosis and oxidative damage in ischemic stroke.

NEURAL REGENERATION RESEARCH (2022)

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Article Rheumatology

Circulating plasma microRNAs in systemic sclerosis-associated pulmonary arterial hypertension

Dirk M. Wuttge et al.

Summary: The study found a link between the expression levels of circulating plasma miRNAs and the occurrence of SSc-APAH in female patients with ACA-positive lcSSc.

RHEUMATOLOGY (2022)

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Article Pharmacology & Pharmacy

LncRNA-Malat1 down-regulates miR-211-5p expression to promote neuronal damage from cerebral ischemia reperfusion injury

Xiaodan Tan et al.

Summary: This study investigated the interaction between LncRNA-Malat1 and miR-2115p in cerebral ischemia reperfusion injury (CIRI). The expression changes of these molecules were found to be negatively correlated with the clinical manifestations of ischemic stroke patients. LncRNA-Malat1 was shown to regulate COX-2 expression through miR-211-5p, contributing to the development of CIRI.

BIOCHEMICAL PHARMACOLOGY (2021)

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Article Biochemistry & Molecular Biology

Expression of miR-200c corresponds with increased reactive oxygen species and hypoxia markers after transient focal ischemia in mice

Oiva Arvola et al.

Summary: This study presents a new protocol for visualizing regional miR-200c expression after experimental stroke in mice, combined with visualization of regional ischemia and oxidative stress markers, which can effectively distinguish ischemic core from surrounding penumbral regions for targeted therapy. The multi-dimensional post-stroke immunofluorescent imaging protocol enables a more detailed investigation into subregional mechanisms, with the goal of developing more effective post-stroke pharmaceutical therapy.

NEUROCHEMISTRY INTERNATIONAL (2021)

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Article Multidisciplinary Sciences

NLRP3 phosphorylation in its LRR domain critically regulates inflammasome assembly

Tingting Niu et al.

Summary: Activation of Nlrp3 inflammasome requires recruitment of Nek7 for ASC speck formation. The phosphorylation status of NLRP3 S803 controls this recruitment, playing a crucial role in inflammasome assembly. These findings suggest that targeting NLRP3 S803 phosphorylation may be a potential strategy for controlling inflammasome-related inflammatory responses.

NATURE COMMUNICATIONS (2021)

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Article Biochemistry & Molecular Biology

Reactive oxygen species trigger NF-κB-mediated NLRP3 inflammasome activation involvement in low-dose CdTe QDs exposure-induced hepatotoxicity

Yanting Pang et al.

Summary: This study found that low-dose exposure to CdTe QDs can activate hepatic macrophages, causing inflammation and oxidative stress. The activation of the NF-kappa B and NLRP3 pathways plays a crucial role in this process.

REDOX BIOLOGY (2021)

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Article Oncology

The mechanisms of colorectal cancer cell mesenchymal-epithelial transition induced by hepatocyte exosome-derived miR-203a-3p

Heyang Xu et al.

Summary: MiR-203a-3p derived from hepatocyte exosomes plays a crucial role in promoting E-cadherin expression and inhibiting Src activity in colorectal cancer cells, leading to reduced invasion rate.

BMC CANCER (2021)

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Article Neurosciences

miR-451 protects against ischemic stroke by targeting Phd3

Mengmeng Wang et al.

Summary: miR-451 plays a protective role in cerebral ischemia by targeting Phd3 and regulating apoptosis through p53 pathway.

EXPERIMENTAL NEUROLOGY (2021)

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Review Biochemistry & Molecular Biology

Dysregulation of microRNA and Intracerebral Hemorrhage: Roles in Neuroinflammation

Hisham Kashif et al.

Summary: Intracerebral hemorrhage (ICH) is a challenging type of stroke with high morbidity and mortality, and currently lacks effective treatment options. Neuroinflammation plays a crucial role in ICH, making microRNAs appealing as potential therapeutic targets for regulating brain inflammation response. Studying the roles of microRNAs in ICH-induced neuroinflammation may provide insights for future research and treatment strategies.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Dysfunction of the Neurovascular Unit in Ischemic Stroke: Highlights on microRNAs and Exosomes as Potential Biomarkers and Therapy

Timea Forro et al.

Summary: Ischemic stroke is a severe global cerebral vascular disease with high disability and mortality rates, where the neurovascular unit (NVU) plays a crucial role. Exosomes mediate cell-to-cell communication within the NVU, with clinical trials showing significant diagnostic and prognostic roles of exosomes in stroke patients.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Multidisciplinary Sciences

Effective silencing of miR-126 after ischemic stroke by means of intravenous α-tocopherol-conjugated heteroduplex oligonucleotide in mice

Motohiro Suzuki et al.

Summary: The study demonstrates the potential of using intravenous delivery of antimiRNAs to brain endothelial cells as an effective strategy in ischemic stroke treatment. The newly developed technology allows for more efficient delivery of miRNA inhibitors, leading to suppression of miRNAs expression and potential therapeutic benefits for ischemic stroke.

SCIENTIFIC REPORTS (2021)

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Article Pharmacology & Pharmacy

Tirbanibulin Attenuates Pulmonary Fibrosis by Modulating Src/STAT3 Signaling

Xin Wang et al.

Summary: Tirbanibulin (KX-01), a novel peptidomimetic Src inhibitor, has shown efficacy in alleviating experimental pulmonary fibrosis by suppressing the p-SRC/p-STAT3 signaling pathways.

FRONTIERS IN PHARMACOLOGY (2021)

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Review Oncology

MicroRNAs as a Potential New Preventive Approach in the Transition from Asymptomatic to Symptomatic Multiple Myeloma Disease

Vanessa Desantis et al.

Summary: Multiple myeloma (MM) is an incurable hematological malignancy characterized by a process that starts from asymptomatic MGUS and progresses to active MM. The identification of early and non-invasive markers for disease progression is actively researched. MicroRNAs (miRNAs) play a significant role as potential diagnostic biomarkers in predicting the clinical transition from MGUS/SMM status to MM.

CANCERS (2021)

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Article Neurosciences

MiR-125a-5p silencing inhibits cerebral ischemia-induced injury through targeting IGFBP3

Bo Song et al.

Summary: This study demonstrated the crucial role of miR-125a-5p in ischemic stroke, showing that silencing it protects the brain from ischemic injury by targeting IGFBP3.

FOLIA NEUROPATHOLOGICA (2021)

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Article Pathology