Ruthenium-catalyzed regioselective N-directed C-H olefination of 2-phenylphthalazinone

The 2-phenylphthalazinone derivatives are the main skeleton of various pharmaceuticals. In this work, an efficient method for the regioselective Ru(II)-organometallic complex-catalyzed alkenylation of 2-phenylphthalazinone through N-directing group via C-H activation process is presented. The results have proved to be satisfactory for a wide range of yields bearing an electron-donating and electron-withdrawing groups on substrates. [GRAPHICS] .

Automated summary

This work presents an efficient method for the regioselective alkenylation of 2-phenylphthalazinone through N-directing group via C-H activation process using Ru(II)-organometallic complex catalyst. Satisfactory results were obtained for a wide range of substrates bearing different electron-donating and electron-withdrawing groups.