期刊
CHEMICAL ENGINEERING JOURNAL
卷 435, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2022.134871
关键词
Microfluidics; Microcapsule; Chemo-sonodynamic therapy; Organoid; Drug delivery
资金
- National Key Research and Development Program of China [2020YFA0908200]
- Strategic Priority Research Program of the Chinese Academy of Science [XDA16021103]
- National Natural Science Foundation of China [52073060, 81671701]
- Shenzhen Fundamental Research Program [JCYJ20190813152616459, JCYJ20210324133214038]
A novel microcapsule delivery system with a perfluorocarbon core carrying oxygen and a hydrogel shell encapsulating an antimetabolite and a sonosensitizer has been developed to enhance the efficacy of chemo-sonodynamic therapy against pancreatic cancer. The system is able to reverse the hypoxic microenvironment, enhance reactive oxygen species production during therapy, and induce cytotoxicity with assistance from the release of the antimetabolite in the presence of low intensity ultrasound. Significant anti-tumor effects have been achieved in patient-derived pancreatic cancer organoid models.
Tumor hypoxia restricts anti-tumor efficacy of aerobic therapies such as chemotherapy and sonodynamic therapy (SDT), and efforts in this area are focused on developing biocompatible and stable oxygen carrying platforms for the anti-tumor treatments. Herein, we present a novel microcapsule delivery system with perfluorocarbon (PFC) core carrying oxygen, and hydrogel shell encapsulating antimetabolite gemcitabine (Gem) and sonosensitizer indocyanine green (ICG) (PO/GI-MCs) for enhancing the efficacy of chemo-sonodynamic therapy against pancreatic cancer. It is demonstrated that the PO/GI-MCs could reverse the hypoxic microenvironment, enhance the reactive oxygen species production during SDT, and induce cytotoxicity with assistance from the simultaneously release of Gem in presence of low intensity ultrasound. The PO/GI-MCs could realize a synergistic therapy and achieve a significantly enhanced anti-tumor effect in patient-derived pancreatic cancer organoid models. Therefore, we believe that the proposed oxygen-carrying microfluidic microcapsules can be an effective strategy for enhancing chemo-sonodynamic therapy for hypoxic tumors.
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