☆ 4.7 Review

Emerging small molecule-engineered hybrid nanomedicines for cancer therapy

CHEMICAL ENGINEERING JOURNAL (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Chemistry, Multidisciplinary

Emerging nanomedicines of paclitaxel for cancer treatment

Qin Chen et al.

Summary: Malignant tumor remains a major threat to human health. Although targeted therapeutic strategies have developed rapidly, treatments that act on a single target are prone to tumor resistance. Therefore, traditional broadspectrum chemotherapy still plays a critical role in clinical cancer therapy. However, most chemotherapeutic drugs have unsatisfactory therapeutic efficacy and severe off-target toxicity. To overcome this, researchers have focused on developing novel nano-formulations for efficient delivery of chemotherapeutic drugs.

JOURNAL OF CONTROLLED RELEASE (2022)

添加到收藏夹

Article Engineering, Biomedical

Carrier-free nanodrugs with efficient drug delivery and release for cancer therapy: From intrinsic physicochemical properties to external modification

Heng Mei et al.

Summary: This review discusses strategies to enhance drug delivery and release of carrier-free nanodrugs for improved cancer therapy. Optimizing the intrinsic physicochemical properties and external modification are key methods.

BIOACTIVE MATERIALS (2022)

添加到收藏夹

Article Engineering, Biomedical

Peptide-based nanomaterials: Self-assembly, properties and applications

Tong Li et al.

Summary: Peptide-based self-assembly nanomaterials, with diverse structures and functionalities, play a significant role in bioapplications. This review provides an overview of the recent advances in peptide-based self-assembly nanostructures, focusing on the driving forces and assembly mechanisms. It also summarizes the synthesis, properties, and applications of functional peptide nanomaterials. The challenges and future prospects of peptide-based nanomaterials are discussed.

BIOACTIVE MATERIALS (2022)

添加到收藏夹

Review Pharmacology & Pharmacy

Recent advances of biomimetic nano-systems in the diagnosis and treatment of tumor

Anning Li et al.

Summary: Biomimetic nano-systems show great potential in tumor therapy, and the strategy of combining nano-systems with biomimetic technology is gaining attention. Challenges and future directions in achieving clinical translation of biomimetic nano-systems are also highlighted.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

Current update on nanoplatforms as therapeutic and diagnostic tools: A review for the materials used as nanotheranostics and imaging modalities

Panoraia Siafaka et al.

Summary: Nanotheranostics, as emerging diagnostic and therapeutic tools, have gained attention in the past decade for their targeted treatment and diagnostic properties, allowing real-time monitoring of therapy response and reducing the risk of dosage errors. Various imaging techniques are used for monitoring drug delivery processes, with radiolabeling of nanomaterials widely used in nuclear medicine imaging.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

添加到收藏夹

Review Chemistry, Multidisciplinary

Recent advances in photothermal and RNA interfering synergistic therapy

Kun Li et al.

Summary: Photothermal therapy (PTT) is a new treatment technique that has attracted worldwide attention in cancer treatment due to its excellent absorption ability, easy regulation, and biodegradability. The synergistic therapy of photothermal and RNA interfering (RNAi) has recently become a hot research topic, showing potential in enhancing the therapeutic effect against tumors.

CHINESE CHEMICAL LETTERS (2021)

添加到收藏夹

Review Chemistry, Multidisciplinary

Erythrocyte-derived drug delivery systems in cancer therapy

Yishen Mao et al.

Summary: Erythrocytes have shown promising potential as drug delivery systems for cancer therapy, particularly in cancer enzyme therapy, delivering chemotherapeutic agents, combining with nanoparticles, and other potential anti-cancer agents for gene or immune therapy. The translation of this novel delivering system from lab to clinical practice is currently underway, with some carriers already in clinical trials and showing promising outcomes. Erythrocyte-derived drug delivery systems may play a crucial role in future cancer management.

CHINESE CHEMICAL LETTERS (2021)

添加到收藏夹

Article Chemistry, Physical

Sonodynamic therapy with immune modulatable two-dimensional coordination nanosheets for enhanced anti-tumor immunotherapy

Wenjun Zhu et al.

Summary: Zn-TCPP 2D nanosheets exhibit enhanced ROS generation for noninvasive SDT and have high loading capacity for oligodeoxynucleotides useful in activating immune responses.

NANO RESEARCH (2021)

添加到收藏夹

Review Chemistry, Multidisciplinary

The Use of Alternative Strategies for Enhanced Nanoparticle Delivery to Solid Tumors

Mukaddes Izci et al.

Summary: Research has shown that despite efforts to utilize the EPR effect for enhanced delivery of nanomaterials to solid tumors, the results are still poor. Furthermore, some studies question the role of the EPR effect, suggesting that nanomaterials may enter tumors through active mechanisms rather than through endothelial gaps.

CHEMICAL REVIEWS (2021)

添加到收藏夹

Article Engineering, Environmental

Precisely engineering a carrier-free hybrid nanoassembly for multimodal DNA damage-augmented photodynamic therapy

Shumeng Li et al.

Summary: This study presents a facile and practical dual-drug co-assembly engineering strategy, constructs an efficient and versatile co-delivery nanoplatform, and demonstrates significant combination anticancer efficacy in vitro and in vivo. The dual-drug hybrid nanoassembly shows potential as a promising nanomedicine for clinical multimodal cancer therapy.

CHEMICAL ENGINEERING JOURNAL (2021)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Engineering precision nanoparticles for drug delivery

Michael J. Mitchell et al.

Summary: The development of nanoparticles has shown promising clinical applications, overcoming the limitations of therapeutic interventions and biological barriers. Precision therapies have enhanced treatment efficacy through personalized interventions. Advancements in nanoparticle design aim to optimize drug delivery, improving efficacy in general applications and enabling tailored designs for precision applications.

NATURE REVIEWS DRUG DISCOVERY (2021)

添加到收藏夹

Article Engineering, Biomedical

Nanodrug with dual-sensitivity to tumor microenvironment for immuno-sonodynamic anti-cancer therapy

Jinsheng Huang et al.

Summary: A novel nanocarrier was developed for tumor-targeted delivery in melanoma to activate anti-tumor immunity and reduce adverse effects. Additionally, combining sonodynamic therapy with immunotherapy effectively promotes anti-cancer immunity and suppresses melanoma growth.

BIOMATERIALS (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Quantitative self-assembly of photoactivatable small molecular prodrug cocktails for safe and potent cancer chemo-photodynamic therapy

Lingling Huang et al.

Summary: The study introduces a facile and versatile strategy to construct self-assembling prodrug cocktail nanoparticles for specific drug activation and cancer chemo-photodynamic therapy. Results from preclinical models show that this nanotherapy can effectively eradicate tumors with substantially low systemic toxicity.

NANO TODAY (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

Investigating the crucial roles of aliphatic tails in disulfide bond-linked docetaxel prodrug nanoassemblies

Yuequan Wang et al.

Summary: The cis-trans configuration of aliphatic tails significantly influences the self-assembly features of prodrugs, and elaidic acid-linked prodrug with a trans double bond show poor self-assembly capacity. Different aliphatic tails significantly influence the chemical stability of prodrugs and the colloidal stability of PNPs, thus affecting the in vivo pharmacokinetics, biodistribution and antitumor efficacy of PNPs.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

Small changes in the length of diselenide bond-containing linkages exert great influences on the antitumor activity of docetaxel homodimeric prodrug nanoassemblies

Lingxiao Li et al.

Summary: The linkages in homodimeric prodrugs play a crucial role in self-assembly, in vivo fate, and antitumor activity. Prolonged linkages can facilitate self-delivery of drugs, improve stability and targeting of nanoassemblies, while reducing cytotoxicity in tumor cells.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Surfactant Protein B Promotes Cytosolic SiRNA Delivery by Adopting a Virus-like Mechanism of Action

Roberta Guagliardo et al.

Summary: This study aimed to gain mechanistic insights into the SP-B-mediated cellular delivery of siRNA and found a strong correlation between SP-B-mediated fusion with endosomal membranes and cytosolic siRNA delivery. These insights may offer opportunities to fuel the rational design of SP-B-inspired RNA nanoformulations for inhalation therapy.

ACS NANO (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

ATP-Responsive Smart Hydrogel Releasing Immune Adjuvant Synchronized with Repeated Chemotherapy or Radiotherapy to Boost Antitumor Immunity

Lele Sun et al.

Summary: A smart hydrogel has been developed to release immune adjuvants in response to repeated low-dose chemo/radiotherapies, enhancing antitumor immunity. By synchronizing the release of immune adjuvants with tumor cell death, the hydrogel demonstrates remarkable synergistic effects in eliminating established tumors and promoting immune memory.

ADVANCED MATERIALS (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Improving Image-Guided Surgical and Immunological Tumor Treatment Efficacy by Photothermal and Photodynamic Therapies Based on a Multifunctional NIR AIEgen

Ruming Jiang et al.

Summary: Multimodal therapy using a multifunctional theranostic nanoplatform based on AIEgen enables preoperative diagnosis, intraoperative fluorescence-guided surgery, and photodynamic and photothermal therapies to efficiently kill tumor cells and significantly improve survival rates.

ADVANCED MATERIALS (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Transformable Nanosensitizer with Tumor Microenvironment-Activated Sonodynamic Process and Calcium Release for Enhanced Cancer Immunotherapy

Xuan Tan et al.

Summary: The study introduces a smart nanosonosensitizer TiO2@CaP which enhances the generation of reactive oxygen species (ROS) under ultrasound activation, inducing mitochondrial dysfunction in the tumor microenvironment and promoting immunogenic cell death, resulting in T-cell infiltration and systemic antitumor immunity. This approach holds promise for developing TME-activatable sonosensitizers with temporospatial control over antitumor responses.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

添加到收藏夹

Article Engineering, Biomedical

Biomimetic co-assembled nanodrug of doxorubicin and berberine suppresses chemotherapy-exacerbated breast cancer metastasis

Xiao Zheng et al.

Summary: Chemotherapy is a double-edged sword in treating breast cancer, as it can induce cancer progression; Berberine has shown potential as a regulator for Dox-exacerbated breast cancer metastasis by targeting the HMGB1-TLR4 axis; The combination of Dox and Ber in a self-assembled nanodrug can effectively inhibit tumor growth and metastasis.

BIOMATERIALS (2021)

添加到收藏夹

Review Engineering, Biomedical

Smart transformable nanomedicines for cancer therapy

Yuequan Wang et al.

Summary: Significant progress has been made in nanoparticulate drug delivery systems, but there are still multiple delivery dilemmas impairing the efficiency of nanomedicines. Smart transformable nanomedicines based on in vivo drug delivery process are promising for overcoming these delivery obstacles. Efforts have been devoted to developing smart transformable anticancer nanomedicines, including size-reducible nanoparticles, transformable nanostructures, and shell-detachable nanocarriers.

BIOMATERIALS (2021)

添加到收藏夹

Article Engineering, Biomedical

A near infrared ratiometric platform based π-extended porphyrin metal-organic framework for O2 imaging and cancer therapy

Bo-Ru Xie et al.

Summary: A newly developed photosensitizer, PTP, can achieve ratiometric oxygen imaging and induce cancer cell death more effectively through photodynamic therapy, combined with immunotherapy to significantly suppress cancer growth and metastasis.

BIOMATERIALS (2021)

添加到收藏夹

Review Chemistry, Multidisciplinary

The progress and perspective of strategies to improve tumor penetration of nanomedicines

Jiang Hu et al.

Summary: This article discusses the importance of tumor penetration, analyzes the barriers to tumor penetration, and discusses strategies such as modulating the tumor microenvironment to enhance tumor penetration.

CHINESE CHEMICAL LETTERS (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Dynamic Continuum of Nanoscale Peptide Assemblies Facilitates Endocytosis and Endosomal Escape

Hongjian He et al.

Summary: This study demonstrates how nanoscale phosphopeptide assemblies cluster ALP to enable cellular uptake through caveolae-mediated endocytosis and endosomal escape. Dephosphorylation of phosphopeptides leads to the formation of peptidic nanofibers for endosomal escape. Inhibiting TNAP or disrupting lipid rafts abolishes the endocytosis process, while decreasing the transformation to nanofibers prevents endosomal escape.

NANO LETTERS (2021)

添加到收藏夹

Review Nanoscience & Nanotechnology

Nanotechnology approaches for global infectious diseases

Ameya R. Kirtane et al.

Summary: Infectious diseases pose a significant burden on global health, particularly in the treatment of diseases like malaria, tuberculosis, and HIV. Nanotechnology shows promise in improving treatment outcomes by enhancing drug targeting and patient adherence.

NATURE NANOTECHNOLOGY (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

Pure photosensitizer-driven nanoassembly with core-matched PEGylation for imaging-guided photodynamic therapy

Shenwu Zhang et al.

Summary: This study demonstrates the development of a core-matched nanoassembly that shows the self-assembly capability of pure PPa molecules into NPs and the improvement of stability and antitumor activity by PPa-PEG(2K).

ACTA PHARMACEUTICA SINICA B (2021)

添加到收藏夹

Article Engineering, Biomedical

Cancer cell membrane camouflaged iridium complexes functionalized black-titanium nanoparticles for hierarchical-targeted synergistic NIR-II photothermal and sonodynamic therapy

Jinchao Shen et al.

Summary: The study introduces a novel method for cancer treatment using functionalized black-titanium nanoparticles, showing satisfactory imaging and therapeutic effects in an animal model.

BIOMATERIALS (2021)

添加到收藏夹

Article Engineering, Biomedical

Self-delivery oxidative stress amplifier for chemotherapy sensitized immunotherapy

Linping Zhao et al.

Summary: A self-delivery oxidative stress amplifier has been developed for chemotherapy sensitized immunotherapy, which can accelerate tumor cell death by breaking intracellular redox homeostasis. The amplifier is able to effectively accumulate in tumor tissues and trigger immunogenic cell death through GSH-responsive drug release.

BIOMATERIALS (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

Interface-sensitized prodrug nanoaggregate as an effective in situ antitumor vaccine

Yaxin Zheng et al.

Summary: The study introduces a simple and effective in situ antitumor vaccine prepared by co-assembling lipid-drug conjugates, demonstrating faster drug release and potential for potent in vivo antitumor immune responses.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

添加到收藏夹

Article Chemistry, Physical

Obstacles and opportunities in a forward vision for cancer nanomedicine

Irene de Lazaro et al.

Summary: This text discusses the biological barriers that have hindered the clinical translation of cancer nanomedicines, and elaborates on new directions for the field that capitalize on a deeper understanding of the nano-bio interface.

NATURE MATERIALS (2021)

添加到收藏夹

Review Chemistry, Multidisciplinary

Small-Molecule Prodrug Nanoassemblies: An Emerging Nanoplatform for Anticancer Drug Delivery

Guanting Li et al.

Summary: SMP-NAs, formed by the self-assembly of prodrugs, have been widely investigated for their ultrahigh drug-loading and minimal adverse reactions, offering potential for improved antitumor efficiency compared to traditional nanomedicines. They are being used in chemotherapy, phototherapy, immunotherapy, and tumor diagnosis, and their co-delivery capabilities can address the challenges of tumor heterogeneity and multidrug resistance. Smart stimuli-responsive SMP-NAs and combination therapies based on SMP-NAs are also highlighted, emphasizing the structure-function relationships.

SMALL (2021)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Molecularly engineered carrier-free co-delivery nanoassembly for self-sensitized photothermal cancer therapy

Xinzhu Shan et al.

Summary: This study presents a novel and convenient dual-drug co-assembly strategy for self-sensitized cancer therapy. The carrier-free co-delivery nanoassembly of a HSP90 inhibitor and DiR demonstrates potential as a new treatment approach for tumors.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Overcoming Chemoimmunotherapy-Induced Immunosuppression by Assemblable and Depot Forming Immune Modulating Nanosuspension

Seung Mo Jin et al.

Summary: A novel immune modulating suspension containing inducers of cell death and supra-adjuvants can effectively increase cytotoxic T lymphocytes and alleviate immune suppression in the tumor microenvironment, leading to enhanced T cell infiltration and inhibition of tumor metastasis. This approach shows promise in increasing the response rate of immune checkpoint blockade therapy, presenting a new nanotheranostic strategy in cancer immunotherapy.

ADVANCED SCIENCE (2021)

添加到收藏夹

Article Engineering, Biomedical

Erythrocyte membrane-camouflaged carrier-free nanoassembly of FRET photosensitizer pairs with high therapeutic efficiency and high security for programmed cancer synergistic phototherapy

Xuanbo Zhang et al.

Summary: Phototherapy as a non-invasive cancer treatment option faces challenges such as unsatisfactory therapeutic efficacy and severe phototoxicity. A new nanoassembly of Forster Resonance Energy Transfer (FRET) photosensitizer pairs has been developed to improve treatment efficiency and safety. The FRET pair-based nanoassembly allows controlled release of photosensitizer for photodynamic therapy, enhancing treatment efficacy while minimizing phototoxicity.

BIOACTIVE MATERIALS (2021)

添加到收藏夹

Review Chemistry, Multidisciplinary

Nanoscale porous organic polymers for drug delivery and advanced cancer theranostics

Nem Singh et al.

Summary: Finding a personalized nano theranostics solution for cancer diagnosis and therapy is a top challenge in current medicinal science. Porous organic polymers (POPs) show remarkable advantages for cancer theranostics due to their specific physicochemical characteristics. Both crystalline and non-crystalline POPs, such as covalent organic frameworks (COFs), have shown potential applications across various research areas. Early research on nanoscale POPs for theranostics has demonstrated promising applications in drug loading, targeted delivery, stimuli-responsive release, cancer imaging, and combination therapy.

CHEMICAL SOCIETY REVIEWS (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Photosensitizer-driven nanoassemblies of homodimeric prodrug for self-enhancing activation and synergistic chemo-photodynamic therapy

Shenwu Zhang et al.

Summary: Carrier-free prodrug-nanoassemblies composed of homodimeric prodrugs driven by a photosensitizer have been developed for self-enhancing activation and chemo-photodynamic synergistic therapy. The nanoassemblies demonstrated potent antitumor activity in a 4T1 breast cancer BALB/c mice xenograft model through alleviating the aggregation-caused quenching effect and synergistically promoting prodrug activation using endogenous and externally induced reactive oxygen species.

THERANOSTICS (2021)

添加到收藏夹

Article Materials Science, Biomaterials

Exploring the self-assembly mechanism and effective synergistic antitumor chemophototherapy of a biodegradable and glutathione responsive ursolic acid prodrug mediated photosensitive nanodrug

Jianjun Cheng et al.

Summary: The study developed a multifunctional small molecule UASS and constructed carrier-free GSH-sensitive photosensitive nanocomposite UASS-Ce6 NPs for safe and synergistically improved chemophototherapy. These nanocomposites showed improved water solubility, enhanced intercellular ROS generation, desirable GSH sensibility, excellent biocompatibility, enhanced tumor accumulation, and rapid biodegradation.

BIOMATERIALS SCIENCE (2021)

添加到收藏夹

Article Materials Science, Biomaterials

A directed co-assembly of herbal small molecules into carrier-free nanodrugs for enhanced synergistic antitumor efficacy

Jiacheng Wang et al.

Summary: Carrier-free nanodrugs co-assembled from two natural small molecules (NSMs) through a supramolecular assembly strategy show rapid cellular uptake, passive tumor targeting, cell cycle arrest, and apoptosis induction, demonstrating synergistic anti-tumor effects. Compared to self-assembled NPs and positive controls, co-assembled NPs exhibit the strongest therapeutic effect in vivo, highlighting the unique advantages of NSMs in terms of biosafety and health benefits. Systemic toxicity and histological examination confirm the reliable biosafety of co-assembled NPs without observed side effects or nano toxicity risks.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

Enhanced stability and efficacy of GEM-TOS prodrug by co-assembly with antimetastatic shell LMWH-TOS

Rong Guo et al.

ACTA PHARMACEUTICA SINICA B (2020)

添加到收藏夹

Review Chemistry, Multidisciplinary

Nanomaterials for Nanotheranostics: Tuning Their Properties According to Disease Needs

Xin Yi Wong et al.

ACS NANO (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Hybrid Nanospheres to Overcome Hypoxia and Intrinsic Oxidative Resistance for Enhanced Photodynamic Therapy

Leilei Shi et al.

ACS NANO (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Biodegradable Nanoscale Coordination Polymers for Targeted Tumor Combination Therapy with Oxidative Stress Amplification

Jingjing Liu et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

A Metal-Polyphenol-Coordinated Nanomedicine for Synergistic Cascade Cancer Chemotherapy and Chemodynamic Therapy

Zhigang Ren et al.

ADVANCED MATERIALS (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Tumor Microenvironment-Activated NIR-II Nanotheranostic System for Precise Diagnosis and Treatment of Peritoneal Metastasis

Sisi Ling et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

添加到收藏夹

Article Engineering, Biomedical

Central metal-derived co-assembly of biomimetic GdTPP/ZnTPP porphyrin nanocomposites for enhanced dual-modal imaging-guided photodynamic therapy

Jiefei Wang et al.

BIOMATERIALS (2020)

添加到收藏夹

Article Oncology

Cancer statistics, 2020

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2020)

添加到收藏夹

Review Chemistry, Multidisciplinary

Advances in aggregatable nanoparticles for tumor-targeted drug delivery

Wenqi Yu et al.

CHINESE CHEMICAL LETTERS (2020)

添加到收藏夹

Review Chemistry, Multidisciplinary

Recent progress in tumor photodynamic immunotherapy

Lijun Shen et al.

CHINESE CHEMICAL LETTERS (2020)

添加到收藏夹

Review Chemistry, Multidisciplinary

Hypoxia-responsive nanoparticle based drug delivery systems in cancer therapy: An up-to-date review

Rashmi Kumari et al.

JOURNAL OF CONTROLLED RELEASE (2020)

添加到收藏夹

Article Oncology

Improving cancer immunotherapy using nanomedicines: progress, opportunities and challenges

John D. Martin et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Gadolinium-Rose Bengal Coordination Polymer Nanodots for MR-/Fluorescence-Image-Guided Radiation and Photodynamic Therapy

Wenjing Sun et al.

ADVANCED MATERIALS (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Tumor-Microenvironment-Triggered Ion Exchange of a Metal-Organic Framework Hybrid for Multimodal Imaging and Synergistic Therapy of Tumors

Ying Chen et al.

ADVANCED MATERIALS (2020)

添加到收藏夹

Article Biophysics

Novel carrier-free nanoparticles composed of 7-ethyl-10-hydroxycamptothecin and chlorin e6: Self-assembly mechanism investigation and in vitro/in vivo evaluation

Yanna Zhao et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2020)

添加到收藏夹

Article Pharmacology & Pharmacy

Squalenoyl-gemcitabine/edelfosine nanoassemblies: Anticancer activity in pediatric cancer cells and pharmacokinetic profile in mice

C. Rodriguez-Nogales et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Tumor microenvironment-activated self-recognizing nanodrug through directly tailored assembly of small-molecules for targeted synergistic chemotherapy

Yang Li et al.

JOURNAL OF CONTROLLED RELEASE (2020)

添加到收藏夹

Review Chemistry, Medicinal

Emerging carrier-free nanosystems based on molecular self-assembly of pure drugs for cancer therapy

Xuanbo Zhang et al.

MEDICINAL RESEARCH REVIEWS (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Synthesis of CaCO3-Based Nanomedicine for Enhanced Sonodynamic Therapy via Amplification of Tumor Oxidative Stress

Ziliang Dong et al.

CHEM (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Dual Hypoxia-Targeting RNAi Nanomedicine for Precision Cancer Therapy

Yujing Li et al.

NANO LETTERS (2020)

添加到收藏夹

Article Engineering, Biomedical

Oxygen-producing catalase-based prodrug nanoparticles overcoming resistance in hypoxia-mediated chemo-photodynamic therapy

Xu Cheng et al.

ACTA BIOMATERIALIA (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Enzymatically Formed Peptide Assemblies Sequestrate Proteins and Relocate Inhibitors to Selectively Kill Cancer Cells

Hongjian He et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

添加到收藏夹

Article Chemistry, Physical

Coordination self-assembly of natural flavonoids into robust nanoparticles for enhanced in vitro chemo and photothermal cancer therapy

Yilin Liu et al.

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS (2020)

添加到收藏夹

Article Nanoscience & Nanotechnology

Lactosylated IR820/DOX Co-Assembled Nanodrug for Synergetic Antitumour Therapy

Yue Jiang et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

添加到收藏夹

Review Chemistry, Multidisciplinary

Controlled anti-cancer drug release through advanced nano-drug delivery systems: Static and dynamic targeting strategies

Farshad Moradi Kashkooli et al.

JOURNAL OF CONTROLLED RELEASE (2020)

添加到收藏夹

Article Nanoscience & Nanotechnology

Nanomedicine-Cum-Carrier by Co-Assembly of Natural Small Products for Synergistic Enhanced Antitumor with Tissues Protective Actions

Jiacheng Wang et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

添加到收藏夹

Review Engineering, Biomedical

Emerging nanotherapeutics for antithrombotic treatment

Zhiqiang Zhao et al.

BIOMATERIALS (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Self-assembly of pentapeptides into morphology-adaptable nanomedicines for enhanced combinatorial chemo-photodynamic therapy

Zhifei Cheng et al.

NANO TODAY (2020)

添加到收藏夹

Review Chemistry, Multidisciplinary

Tumor microenvironment-responsive intelligent nanoplatforms for cancer theranostics

Fei Gong et al.

NANO TODAY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

An RNA vaccine drives immunity in checkpoint-inhibitor-treated melanoma

Ugur Sahin et al.

NATURE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Preparation of TiH1.924 nanodots by liquid-phase exfoliation for enhanced sonodynamic cancer therapy

Fei Gong et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Review Chemistry, Multidisciplinary

Dimeric prodrug-based nanomedicines for cancer therapy

Shumeng Li et al.

JOURNAL OF CONTROLLED RELEASE (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Probing the Superiority of Diselenium Bond on Docetaxel Dimeric Prodrug Nanoassemblies: Small Roles Taking Big Responsibilities

Shiyi Zuo et al.

SMALL (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Photosensitizer-stabilized self-assembling nanoparticles potentiate chemo/photodynamic efficacy of patient-derived melanoma

Lingling Huang et al.

JOURNAL OF CONTROLLED RELEASE (2020)

添加到收藏夹

Review Multidisciplinary Sciences

Engineering microrobots for targeted cancer therapies from a medical perspective

Christine K. Schmidt et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Trisulfide bond-mediated doxorubicin dimeric prodrug nanoassemblies with high drug loading, high self-assembly stability, and high tumor selectivity

Yinxian Yang et al.

SCIENCE ADVANCES (2020)

添加到收藏夹

Review Oncology

Nanotherapeutics for Antimetastatic Treatment

Fujun Yang et al.

TRENDS IN CANCER (2020)

添加到收藏夹

Article Medicine, Research & Experimental

Cytochrome P450 enzyme-mediated auto-enhanced photodynamic cancer therapy of co-nanoassembly between clopidogrel and photosensitizer

Qiu Wang et al.

THERANOSTICS (2020)

添加到收藏夹

Review Pharmacology & Pharmacy

Emerging nanoparticulate drug delivery systems of metformin

Yao Chen et al.

JOURNAL OF PHARMACEUTICAL INVESTIGATION (2020)

添加到收藏夹

Article Engineering, Biomedical

Near-infrared AIEgens as transformers to enhance tumor treatment efficacy with controllable self-assembled redox-responsive carrier-free nanodrug

Wei Zhang et al.

BIOMATERIALS (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Nanoscale Coordination Polymers for Synergistic NO and Chemodynamic Therapy of Liver Cancer

Yihui Hu et al.

NANO LETTERS (2019)

添加到收藏夹

Article Chemistry, Physical

Albumin-bound paclitaxel dimeric prodrug nanoparticles with tumor redox heterogeneity-triggered drug release for synergistic photothermal/chemotherapy

Qing Pei et al.

NANO RESEARCH (2019)

添加到收藏夹

Review Chemistry, Multidisciplinary

Combining Nanomedicine and Immunotherapy

Yang Shi et al.

ACCOUNTS OF CHEMICAL RESEARCH (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

A Mn(III)-Sealed Metal-Organic Framework Nanosystem for Redox-Unlocked Tumor Theranostics

Shuang-Shuang Wan et al.

ACS NANO (2019)

添加到收藏夹

Article Engineering, Biomedical

Photodynamic PEG-coated ROS-sensitive prodrug nanoassemblies for core-shell synergistic chemo-photodynamic therapy

Bingjun Sun et al.

ACTA BIOMATERIALIA (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

A Biomimetic Coordination Nanoplatform for Controlled Encapsulation and Delivery of Drug-Gene Combinations

Bei Liu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Self-facilitated ROS-responsive nanoassembly of heterotypic dimer for synergistic chemo-photodynamic therapy

Cong Luo et al.

JOURNAL OF CONTROLLED RELEASE (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Probing the impact of sulfur/selenium/carbon linkages on prodrug nanoassemblies for cancer therapy

Bingjun Sun et al.

NATURE COMMUNICATIONS (2019)

添加到收藏夹

Review Pharmacology & Pharmacy

Cancer nanotechnology: Enhancing tumor cell response to chemotherapy for hepatocellular carcinoma therapy

Yongbing Sun et al.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Heterochiral Assembly of Amphiphilic Peptides Inside the Mitochondria for Supramolecular Cancer Therapeutics

M. T. Jeena et al.

ACS NANO (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Self-Amplified Drug Delivery with Light-Inducible Nanocargoes to Enhance Cancer Immunotherapy

Bing Feng et al.

ADVANCED MATERIALS (2019)

添加到收藏夹

Review Chemistry, Multidisciplinary

Modular Design of Peptide- or DNA-Modified AlEgen Probes for Biosensing Applications

Fan Xia et al.

ACCOUNTS OF CHEMICAL RESEARCH (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Nanoscale Coordination Polymer Based Nanovaccine for Tumor Immunotherapy

He Zhao et al.

ACS NANO (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

A Nanobody-Conjugated DNA Nanoplatform for Targeted Platinum-Drug Delivery

Tiantian Wu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Engineering Multifunctional DNA Hybrid Nanospheres through Coordination-Driven Self-Assembly

Mengyuan Li et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

添加到收藏夹

Article Engineering, Biomedical

Mitochondria and plasma membrane dual-targeted chimeric peptide for single-agent synergistic photodynamic therapy

Hong Cheng et al.

BIOMATERIALS (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Self-Assembled Copper Amino Acid Nanoparticles for in Situ Glutathione AND H2O2 Sequentially Triggered Chemodynamic Therapy

Baojin Ma et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

添加到收藏夹

Review Chemistry, Multidisciplinary

Nanoparticles-based magnetic and photo induced hyperthermia for cancer treatment

S. K. Sharma et al.

NANO TODAY (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Reducing aggregation caused quenching effect through co-assembly of PAH chromophores and molecular barriers

Yinjuan Huang et al.

NATURE COMMUNICATIONS (2019)

添加到收藏夹

Review Pharmacology & Pharmacy

The application of nitric oxide delivery in nanoparticle-based tumor targeting drug delivery and treatment

Lin Qin et al.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Nanoengineered Immune Niches for Reprogramming the Immunosuppressive Tumor Microenvironment and Enhancing Cancer Immunotherapy

Hathaichanok Phuengkham et al.

ADVANCED MATERIALS (2019)

添加到收藏夹

Article Materials Science, Biomaterials

Kinetic stability-driven cytotoxicity of small-molecule prodrug nanoassemblies

Yang Li et al.

JOURNAL OF MATERIALS CHEMISTRY B (2019)

添加到收藏夹

Review Medicine, Research & Experimental

Peptide-modulated self-assembly as a versatile strategy for tumor supramolecular nanotheranostics

Shukun Li et al.

THERANOSTICS (2019)

添加到收藏夹

Review Oncology

Improving cancer immunotherapy through nanotechnology

Michael S. Goldberg

NATURE REVIEWS CANCER (2019)

添加到收藏夹

Article Pharmacology & Pharmacy

Co-encapsulation of docetaxel and cyclosporin A into SNEDDS to promote oral cancer chemotherapy

Weiping Cui et al.

DRUG DELIVERY (2019)

添加到收藏夹

Review Multidisciplinary Sciences

The acidic tumor microenvironment: a target for smart cancer nano-theranostics

Liangzhu Feng et al.

NATIONAL SCIENCE REVIEW (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

Hypochlorous Acid Promoted Platinum Drug Chemotherapy by Myeloperoxidase-Encapsulated Therapeutic Metal Phenolic Nanoparticles

Yunlu Dai et al.

ACS NANO (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

Light-Activatable Red Blood Cell Membrane-Camouflaged Dimeric Prodrug Nanoparticles for Synergistic Photodynamic/Chemotherapy

Qjng Pei et al.

ACS NANO (2018)

添加到收藏夹

Article Engineering, Biomedical

Carrier-free nanodrug by co-assembly of chemotherapeutic agent and photosensitizer for cancer imaging and chemo-photo combination therapy

Ruirui Zhao et al.

ACTA BIOMATERIALIA (2018)

添加到收藏夹

Article Engineering, Biomedical

Versatile hyaluronic acid modified AQ4N-Cu(II)-gossypol infinite coordination polymer nanoparticles: Multiple tumor targeting, highly efficient synergistic chemotherapy, and real-time self-monitoring

Shihong Shen et al.

BIOMATERIALS (2018)

添加到收藏夹

Article Pharmacology & Pharmacy

Dipeptide-modified nanoparticles to facilitate oral docetaxel delivery: new insights into PepT1-mediated targeting strategy

Yuqian Du et al.

DRUG DELIVERY (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

High Drug Loading and Sub-Quantitative Loading Efficiency of Polymeric Micelles Driven by Donor-Receptor Coordination Interactions

Shixian Lv et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

Disulfide Bond-Driven Oxidation- and Reduction-Responsive Prodrug Nanoassemblies for Cancer Therapy

Bingjun Sun et al.

NANO LETTERS (2018)

添加到收藏夹

Article Chemistry, Physical

Quantitative self-assembly prediction yields targeted nanomedicines

Yosi Shamay et al.

NATURE MATERIALS (2018)

添加到收藏夹

Review Pharmacology & Pharmacy

ROS-responsive drug delivery systems for biomedical applications

Wenhui Tao et al.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2018)

添加到收藏夹

Article Nanoscience & Nanotechnology

Self-Assembly of a Pure Photosensitizer as a Versatile Theragnostic Nanoplatform for Imaging-Guided Antitumor Photothermal Therapy

Xuanbo Zhang et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

Binary Cooperative Prodrug Nanoparticles Improve Immunotherapy by Synergistically Modulating Immune Tumor Microenvironment

Bing Feng et al.

ADVANCED MATERIALS (2018)

添加到收藏夹

Article Biophysics

Vitamin E-based redox-sensitive salinomycin prodrug-nanosystem with paclitaxel loaded for cancer targeted and combined chemotherapy

De-Sheng Liang et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2018)

添加到收藏夹

Review Chemistry, Multidisciplinary

Tumor-Acidity-Cleavable Maleic Acid Amide (TACMAA): A Powerful Tool for Designing Smart Nanoparticles To Overcome Delivery Barriers in Cancer Nanomedicine

Jin-Zhi Du et al.

ACCOUNTS OF CHEMICAL RESEARCH (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

G-Quadruplex-Based Nanoscale Coordination Polymers to Modulate Tumor Hypoxia and Achieve Nuclear-Targeted Drug Delivery for Enhanced Photodynamic Therapy

Yu Yang et al.

NANO LETTERS (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

Doxorubicin delivered by a redox-responsive dasatinib-containing polymeric prodrug carrier for combination therapy

Jingjing Sun et al.

JOURNAL OF CONTROLLED RELEASE (2017)

添加到收藏夹

Article Chemistry, Multidisciplinary

Bisphosphonate-functionalized coordination polymer nanoparticles for the treatment of bone metastatic breast cancer

Yuanfeng He et al.

JOURNAL OF CONTROLLED RELEASE (2017)

添加到收藏夹

Article Chemistry, Multidisciplinary

Drug-induced co-assembly of albumin/catalase as smart nano-theranostics for deep intra-tumoral penetration, hypoxia relieve, and synergistic combination therapy

Qian Chen et al.

JOURNAL OF CONTROLLED RELEASE (2017)

添加到收藏夹

Article Medicine, Research & Experimental

Cancer Nanomedicines Stabilized by π-π Stacking between Heterodimeric Prodrugs Enable Exceptionally High Drug Loading Capacity and Safer Delivery of Drug Combinations

Hangxiang Wang et al.

THERANOSTICS (2017)

添加到收藏夹

Review Oncology

Cancer nanomedicine: progress, challenges and opportunities

Jinjun Shi et al.

NATURE REVIEWS CANCER (2017)

添加到收藏夹

Article Chemistry, Multidisciplinary

Supramolecular Assembly of Peptide Amphiphiles

Mark P. Hendricks et al.

ACCOUNTS OF CHEMICAL RESEARCH (2017)

添加到收藏夹

Article Biochemical Research Methods

Gemcitabine Integrated Nano-Prodrug Carrier System

Seren Hamsici et al.

BIOCONJUGATE CHEMISTRY (2017)

添加到收藏夹

Article Engineering, Biomedical

Transferrin-inspired vehicles based on pH-responsive coordination bond to combat multidrug-resistant breast cancer

Yu-Jing He et al.

BIOMATERIALS (2017)

添加到收藏夹

Article Chemistry, Physical

Self-delivery of a peptide-based prodrug for tumor-targeting therapy

Mengyun Peng et al.

NANO RESEARCH (2016)

添加到收藏夹

Article Nanoscience & Nanotechnology

Paclitaxel-Paclitaxel Prodrug Nanoassembly as a Versatile Nanoplatform for Combinational Cancer Therapy

Xiangfei Han et al.

ACS APPLIED MATERIALS & INTERFACES (2016)

添加到收藏夹

Article Chemistry, Physical

Breakdown of the adiabatic Born-Oppenheimer approximation in graphene

Simone Pisana et al.

NATURE MATERIALS (2007)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.