期刊
CHEMICAL ENGINEERING JOURNAL
卷 435, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2021.134466
关键词
Drug delivery; Diabetic mice; Carbon-coated magnetic nanoparticles; Graphene; Cytotoxicity
资金
- Horizon 2020 BIORIMA project
- Hong Kong Research Grant Council [E-HKUST601/17]
- Project of Hetao Shenzhen-Hong Kong University of Science and Technology Innovation Cooperation Zone [HZQB-KCZYB-2020083]
- HKJEBN Scholarship
- HKUST Overseas Research Award
- Spanish Ministerio de Economia y Competitividad (MINECO) [PI16/00496, PI19/00349]
- Spanish Ministerio Ciencia e innovaccion (MICINN) [DTS19/00033]
- ERDF/ESF, Investing in Your Future
- MCIN/AEI [PID2019-106947RB-C21]
- CSIC [PIE 201960E119]
- Regional Government of Aragon (DGA) [E28_20R]
- Central Facilities of the Hong Kong University of Science and Technology including the Material Characterization and Preparation Facility (MCPF)
- Environmental Central Facility (ENVF)
- Animal and Plant Care Facility (APCF)
- Servicio General de Apoyo a la Investigacion-SAI of the University of Zaragoza
- Advanced Microscopy Laboratory (LMA) of the University of Zaragoza
The study found that iron nanoparticles encapsulated within graphene shells (Fe@C) have good biocompatibility and high drug loading capacity. Compared to other nanoparticles, Fe@C has lower cytotoxicity and can release drugs continuously.
Iron nanoparticles encapsulated within graphene shells (Fe@C) were examined for cellular internalization, subcellular behavior, biocompatibility, and influence on cell viability and proliferation. Studies on human lung (adenocarcinoma human alveolar basal epithelial) and skin (epidermoid carcinoma) cells indicate Fe@C is less toxic and more biocompatible than the magnetite nanoparticles coated by an amorphous carbon (Fe3O4@C). Fe3O4@C exhibited more signs of degradation than Fe@C when exposed to murine macrophages (mouse monocyte-macrophages J774). Unlike Fe3O4@C, Fe@C has a high drug loading capacity (0.18 g/g) for ferulic acid, an active pharmaceutical ingredient found in the traditional Chinese herb Angelica sinensis and releases the drug at a constant dosing rate of 8.75 mg/g/day over 30 days. Ferulic acid released by Fe@C injected subcutaneously in diabetic BALB/c mice is effective in lowering the blood glucose level.
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