4.4 Article

Tetraphenylporphyrin Enters the Ring: First Example of a Complex between Highly Bulky Porphyrins and a Protein

期刊

CHEMBIOCHEM
卷 23, 期 14, 页码 -

出版社

WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.202200095

关键词

drug delivery; heme proteins; protein structures; Pseudomonas aeruginosa; tetraphenylporphyrin

资金

  1. JSPS KAKENHI [JP15H05806, JP18H02084, JP18J15250, JP21J15614, JP18J23340]
  2. JST CREST [JPMJCR15P3]
  3. SUNBOR scholarship from the SUNTORY FOUNDATION for LIFE SCIENCES

向作者/读者索取更多资源

A stable complex between HasA and TPP was reported, which can inhibit the growth of Pseudomonas aeruginosa and mutant variants of HasA binding FeTPP show a different coordination mode that allows the cyclopropanation of styrene.
Tetraphenylporphyrin (TPP) is a symmetrically substituted synthetic porphyrin whose properties can be readily modified, providing it with significant advantages over naturally occurring porphyrins. Herein, we report the first example of a stable complex between a native biomolecule, the haemoprotein HasA, and TPP as well as its derivatives. The X-ray crystal structures of nine different HasA-TPP complexes were solved at high resolutions. HasA capturing TPP derivatives was also demonstrated to inhibit growth of the opportunistic pathogen Pseudomonas aeruginosa. Mutant variants of HasA binding FeTPP were shown to possess a different mode of coordination, permitting the cyclopropanation of styrene.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.4
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据